肥胖婦女減重後對體組成及血脂質之影響

Epidemiological studies have shown that obesity correlates positively with incidence of chronic diseases, and weight reduction ameliorates the severity of the diseases. Most domestic studies for obesity done previously were epidemiological studies. Reports concerning the difference between various parameters before and after weight reduction are rare. The aim of this study was to investigate the changes in body composition, and plasma lipids before and after weight reduction in obese women. Sixty-seven premenopausal obese women were recruited into the study, and consequently divided into mildly obese group with their body mass index (BMI) ranged from 26.4 to 30.7, and moderately obese group with their BMI over 30.8. All obese women were kept on low calorie diet control for half a year. Eighteen normal weight age-matched women served as control. The results revealed that body fat mass and fat free mass were significantly different among the nonobese, mildly obese and moderately obese groups. Among the 67 subjects, only 29 women reduced more than 5% of their initial body weight. The mean weight loss of these subjects was 9.2±5.2kg (79.6±13.8kg vs 70.4±11.2kg). Body fat content was reduced by 3.6±2.3% (35.8±3.6% vs 32.2±3.4%) after weight reduction. Plasma triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), LDL-C and high density lipoprotein-cholesterol (HDL-C) ratio and apolipoprotein B (Apo B) concentrations were significantly higher, whereas HDL-C level was lower in moderately obese group than in the mildly obese group. Weight reduction of the obese women significantly lowered the plasma concentrations TG, TC, LDL-C and LDL-C/HDL-C ratio. Although HDL-C was significantly increased after weight reduction, the concentration of HDL-C of the obese groups was still lower than that of the nonobese group. In conclusion, results of this study revealed that weight loss of more than 5% of initial body weight of the obese women significantly improved the plasma lipid profiles. No significant differences of plasma lipid concentrations were seen among the obese women with different levels of weight reduction.