@article{99d975ef8706492f8cdfff122830bac5,
title = "ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression",
abstract = "The transcription factor GATA3 is the master regulator that drives mammary luminal epithelial cell differentiation and maintains mammary gland homeostasis. Loss of GATA3 is associated with aggressive breast cancer development. We have identified ZNF503/ZEPPO2 zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional repressor of GATA3 expression and transcriptional activity that induces mammary epithelial cell proliferation and breast cancer development. We show that ZPO2 is recruited to GATA3 promoter in association with ZBTB32 (Repressor of GATA, ROG) and that ZBTB32 is essential for downregulation of GATA3 via ZPO2. Through this modulation of GATA3 activity, ZPO2 promotes aggressive breast cancer development. Our data provide insight into a mechanism of GATA3 regulation, and identify ZPO2 as a possible candidate gene for future diagnostic and therapeutic strategies.",
keywords = "Breast cancer, GATA3, Tumor metastasis, ZBTB32, ZNF503/ZPO2",
author = "Payam Shahi and Wang, {Chih Yang} and Lawson, {Devon A.} and Slorach, {Euan M.} and Angela Lu and Ying Yu and Lai, {Ming Derg} and Velozo, {Hugo Gonzalez} and Zena Werb",
note = "Funding Information: We thank Dr. I. Cheng Ho for the Zbtb32 construct; Dr. Hope Rugo (University of California, San Francisco) for the donation of tumor samples; and Vicki Plaks, Amy-Jo Casbon, Caroline Bonnans, Kai Kessenbrock, Ken Takai, and Elena Atamanuic for their support and intellectual discussions. This research was funded by National Cancer Institute Grants R01 CA180039 and R01 CA190851 (to Z.W.), and Traineeship T32 CA108462 (to P.S.). This work was supported by Taiwan Ministry of Science and Technology Grant 104-2917-I-006-002 (to C.W.), US Department of Defense Congressionally Directed Medical Research Program Postdoctoral Fellowship 11-1-0742 (to D.A.L.), and a Becas Chile Scholarship (H.G.V.).",
year = "2017",
month = mar,
day = "21",
doi = "10.1073/pnas.1701690114",
language = "English",
volume = "114",
pages = "3169--3174",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "12",
}
