Well-ordered mesoporous silica nanoparticles as cell markers

Yu Shen Lin; Chih Pin Tsai; Hsing Yi Huang; Chieh Ti Kuo; Yann Hung; Dong Ming Huang; Yao Chang Chen; Chung Yuan Mou

doi:10.1021/cm051014c

Well-ordered mesoporous silica nanoparticles as cell markers

Yu Shen Lin, Chih Pin Tsai, Hsing Yi Huang, Chieh Ti Kuo, Yann Hung, Dong Ming Huang, Yao Chang Chen, Chung Yuan Mou

研究成果: 雜誌貢獻 › 文章 › 同行評審

420 引文斯高帕斯（Scopus）

摘要

Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.

原文	英語
頁（從 - 到）	4570-4573
頁數	4
期刊	Chemistry of Materials
卷	17
發行號	18
DOIs	https://doi.org/10.1021/cm051014c
出版狀態	已發佈 - 9月 6 2005
對外發佈	是

ASJC Scopus subject areas

化學 (全部)
化學工程 (全部)
材料化學

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10.1021/cm051014c

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author = "Lin, {Yu Shen} and Tsai, {Chih Pin} and Huang, {Hsing Yi} and Kuo, {Chieh Ti} and Yann Hung and Huang, {Dong Ming} and Chen, {Yao Chang} and Mou, {Chung Yuan}",

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AU - Lin, Yu Shen

AU - Tsai, Chih Pin

AU - Huang, Hsing Yi

AU - Kuo, Chieh Ti

AU - Hung, Yann

AU - Huang, Dong Ming

AU - Chen, Yao Chang

AU - Mou, Chung Yuan

PY - 2005/9/6

Y1 - 2005/9/6

N2 - Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.

AB - Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.

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JO - Chemistry of Materials

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Well-ordered mesoporous silica nanoparticles as cell markers

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