摘要
The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P
原文 | 英語 |
---|---|
頁(從 - 到) | 730-733 |
頁數 | 4 |
期刊 | Pharmacogenetics and Genomics |
卷 | 19 |
發行號 | 9 |
DOIs | |
出版狀態 | 已發佈 - 9月 2009 |
ASJC Scopus subject areas
- 遺傳學
- 分子生物學
- 分子醫學
- 遺傳學(臨床)