Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao; Lawrence Shih Hsin Wu; Shih Yi Huang; Eugene Lin

doi:10.1097/FPC.0b013e3283307cf1

Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao, Lawrence Shih Hsin Wu, Shih Yi Huang, Eugene Lin

研究成果: 雜誌貢獻 › 文章 › 同行評審

35 引文斯高帕斯（Scopus）

摘要

The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

原文	英語
頁（從 - 到）	730-733
頁數	4
期刊	Pharmacogenetics and Genomics
卷	19
發行號	9
DOIs	https://doi.org/10.1097/FPC.0b013e3283307cf1
出版狀態	已發佈 - 9月 2009

ASJC Scopus subject areas

遺傳學
分子生物學
分子醫學
遺傳學（臨床）

UN SDG

此研究成果有助於以下永續發展目標

存取文件

10.1097/FPC.0b013e3283307cf1

其它文件與鏈接

Link to publication in Scopus

引用此

@article{2e0db9b4a9264f1ba54e96591cfd3c9c,

title = "Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene",

abstract = "The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P",

keywords = "Body fat, Obesity, Sibutramine, Single nucleotide polymorphisms, Weight loss",

author = "Hsiao, {Dun Jen} and Wu, {Lawrence Shih Hsin} and Huang, {Shih Yi} and Eugene Lin",

year = "2009",

month = sep,

doi = "10.1097/FPC.0b013e3283307cf1",

language = "English",

volume = "19",

pages = "730--733",

journal = "Pharmacogenetics",

issn = "1744-6872",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

AU - Hsiao, Dun Jen

AU - Wu, Lawrence Shih Hsin

AU - Huang, Shih Yi

AU - Lin, Eugene

PY - 2009/9

Y1 - 2009/9

N2 - The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

AB - The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

KW - Body fat

KW - Obesity

KW - Sibutramine

KW - Single nucleotide polymorphisms

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=70249136845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70249136845&partnerID=8YFLogxK

U2 - 10.1097/FPC.0b013e3283307cf1

DO - 10.1097/FPC.0b013e3283307cf1

M3 - Article

C2 - 19687782

AN - SCOPUS:70249136845

SN - 1744-6872

VL - 19

SP - 730

EP - 733

JO - Pharmacogenetics

JF - Pharmacogenetics

IS - 9

ER -

Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

摘要

ASJC Scopus subject areas

UN SDG

存取文件

其它文件與鏈接

指紋

引用此