Visfatin-a proinflammatory adipokine-in gallstone disease

Shen Nien Wang, Yao Tsung Yeh, Sen Teh Wang, Shih Chang Chuang, Chao Ling Wang, Ming Lung Yu, King Teh Lee

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)


Background: Visfatin is increasingly associated with several obesity-related diseases. The study is to evaluate if aberrant expression of circulating visfatin occurs in gallstone disease. Methods: An enzyme-linked immunosorbent assay was used to examine serum visfatin levels in 79 patients with cholesterol gallstones, 71 with pigment gallstones, and 223 healthy controls. The chemical composition of extracted gallstones was determined by Fourier transform infrared spectroscopy. Results: Serum visfatin levels were markedly elevated in the cholesterol and pigment gallstones in comparison with healthy controls. Furthermore, increased visfatin levels were associated with formation of the cholesterol and pigment gallstones. Intriguingly, a significant positive correlation between serum visfation levels and white cell count was noted in the cholesterol gallstones and controls. Moreover, the positive correlation in the cholesterol gallstones was more significant in the body mass index ≥25 subgroup than in the body mass index

頁(從 - 到)459-465
期刊American Journal of Surgery
出版狀態已發佈 - 4月 2010

ASJC Scopus subject areas

  • 手術


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