@article{ca88fff68aa24283b40e2352cdebf639,
title = "Ventricular arrhythmias in nonischemic cardiomyopathy",
abstract = "Nonischemic cardiomyopathies (NICMs) are composed of variable disease entities, including primary and secondary cardiomyopathies. Determining the etiology of NICM provides pivotal roles of not only the understanding of the individual pathogenesis, but also the clinical management, such as risk stratification, pharmacological treatment, and intervention therapies. Despite the diverse causes of NICM, these cases mostly require clinical attention owing to progressive myocardial injury, resulting in ventricular dysfunction and heart failure. The interaction between the diseased ventricular substrates and systemic/neurophysiological factors contributes to the cornerstones responsible for ventricular arrhythmogenesis and sudden cardiac death (SCD). Prevention of SCD and diminishing ventricular tachyarrhythmias are the important mainstays for the management of NICM patients. Given the understanding of the abnormal ventricular substrates and advancement of navigation systems, radiofrequency catheter ablation (RFCA) has become an adjunctive or alternative strategy for NICM patients who experience drug-refractory ventricular tachycardias (VTs). Successful ablation can frequently be achieved at the expense of an epicardial intervention. A recent study has proven the survival benefits for NICM patients who are free from recurrent VTs after a successful RFCA, regardless of the New York Heart Association (NYHA) functional class status or left ventricular ejection fraction. Additionally, recent evidence has highlighted the better delineation of a diseased myocardium through the incorporation of cardiovascular magnetic resonance imaging (CMRI) and 3D mapping systems, which can facilitate the identification of critical ventricular arrhythmogenic substrates in NICM patients.",
keywords = "Arrhythmogenic substrate, Cardiovascular magnetic resonance imaging, Catheter ablation, Implantable cardioverter-defibrillator, Sudden cardiac death",
author = "Chung, {Fa Po} and Lin, {Chin Yu} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Lo, {Li Wei} and Hu, {Yu Feng} and Tuan, {Ta Chuan} and Chao, {Tze Fan} and Liao, {Jo Nan} and Chang, {Yao Ting} and Chang, {Ting Yung} and Lin, {Chung Hsing} and Te, {Abigail Louise D.} and Shinya Yamada and Chen, {Shih Ann}",
note = "Funding Information: Center for Dynamical Biomarkers and Translational Medicine, Ministry of Science and Technology, Grant/Award Number: MOST104-2314-B-075-089-MY3, MOST 103-2911-I-008-001, MOST103-2314-B-075-089-MY3, NSC 102-2314-B-010-056-MY2; Research Foundation of Cardiovascular Medicine, Grant/Award Number: RFCM 104-01-012, RFCM 105-02- 028, RFCM 105-02-008, RFCM 105-02- 028; TVGH-NTUH Joint Research Program, Grant/Award Number: VGHUST105-G7-4-1, VN103-04; Szu-Yuan Research Foundation of Internal Medicine, Grant/Award Number: 106003; Taipei Veterans General Hospital, Grant/Award Number: V103C-042, V104B-018, V104E7-001, V104C-109, V105B-014, V105C-122, V105C-116, V106C-158, V106B-010 Funding Information: This work was supported by the Center for Dynamical Biomarkers and Translational Medicine, Ministry of Science and Technology (Grant No. MOST104-2314-B-075-089-MY3, MOST 103-2911-I-008-001, MOST103-2314-B-075-089-MY3, NSC 102-2314-B-010-056-MY2), Research Foundation of Cardiovascular Medicine (Grant No. RFCM 104-01-012, RFCM 105-02-028, RFCM 105-02-008, and RFCM 105-02-028), TVGH-NTUH Joint Research Program (Grant No. VGHUST105-G7-4-1), Szu-Yuan Research Foundation of Internal Medicine (Grant No. 106003), TVGH-NTUH Joint Research Program (Grant No. VN103-04), and Taipei Veterans General Hospital (Grant No. V103C-042, V104B-018, V104E7-001, V104C-109, V105B-014, V105C-122, V105C-116, V106C-158, and V106B-010).",
year = "2018",
month = aug,
doi = "10.1002/joa3.12028",
language = "English",
volume = "34",
pages = "336--346",
journal = "Journal of Arrhythmia",
issn = "1880-4276",
publisher = "Elsevier BV",
number = "4",
}