VALIDATION DES PROPRIETES RHEOLOGIQUES D'UNE COLLE DE FIBRINE: LE BIOCOL®-THROMBINE HUMAINE

P. Duval, B. Flan, T. Burnouf, J. J. Huart

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Rheological properties of one of the main fibrin glues, 'Biocol-Thrombine Humaine', prepared by the Regional Blood Transfusion Center of Lille (France) were measured with a CSL controlled stress rheometer using cone-plates and parallel plates. The parameters followed were the dynamic viscosity of the fibrinogen concentrate, the gelification time, the breaking point in a destructive test and the development of elasticity of the fibrin clots according to time or frequency. The results showed that the fibrinogen concentrate of 'Biocol-Thrombine Humaine' has a flow curve near that of Newtonian flow, and that its dynamic viscosity at 20 °C is about 100 mPa.s. The gelification time of the fibrinogen-thrombin mixture is very short (under 10 seconds). The breaking point is high, showing a great strength of the fibrin clots. The development of elasticity after mixing is very quick. It is also independent of the frequency shearing. The validation of these rheological tests provides data supporting their use in the assessment of the physical properties of fibrin glue in place of the currently used test based on the gluing of mouse skin.

貢獻的翻譯標題Validation of the rheological properties of a fibrin glue: Biocol®-Thrombine Humaine
原文法語
頁(從 - 到)43-52
頁數10
期刊Annales Pharmaceutiques Francaises
52
發行號1
出版狀態已發佈 - 1994
對外發佈

ASJC Scopus subject areas

  • 藥學科學

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