@article{c17f22d479de47dfa2147b211fc2f2da,
title = "Uterine sarcoma Part II—Uterine endometrial stromal sarcoma: The TAG systematic review",
abstract = "Endometrial stromal tumors are rare uterine tumors (<1%). Four main categories include endometrial stromal nodule, low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and uterine undifferentiated sarcoma (UUS). This review is a series of articles discussing the uterine sarcomas. LG-ESS, a hormone-dependent tumor harboring chromosomal rearrangement, is an indolent tumor with a favorable prognosis, but characterized by late recurrences even in patients with Stage I disease, suggesting the requirement of a long-term follow-up. Patients with HG-ESS, based on the identification of YWHAE-NUTM2A/B (YWHAE-FAM22A/B) gene fusion, typically present with advanced stage diseases and frequently have recurrences, usually within a few years after initial surgery. UUS is, a high-grade sarcoma, extremely rare, lacking a specific line of differentiation, which is a diagnosis of exclusion (the wastebasket category, which fails to fulfill the morphological and immunohistochemical criteria of translocation-positive ESS). Surgery is the main strategy in the management of uterine sarcoma. Due to rarity, complex biological characteristics, and unknown etiology and risk factors of uterine sarcomas, the role of adjuvant therapy is not clear. Only LG-ESS might respond to progestins or aromatase inhibitors.",
keywords = "diagnosis, endometrial stromal sarcoma, treatment, undifferentiated sarcoma, uterine sarcoma, uterus",
author = "Horng, {Huann Cheng} and Wen, {Kuo Chang} and Wang, {Peng Hui} and Chen, {Yi Jen} and Yen, {Ming Shyen} and Ng, {Heung Tat} and Chang, {Yen Hou} and Yi Chang and Chao, {Hsiang Tai} and Chao, {Kuan Chong} and Chuang, {Chi Mu} and Ho, {Chi Hong} and Huang, {Chen Yu} and Hung, {Zhi Chen} and Jiang, {Ling Yu} and Lau, {Hei Yu} and Li, {Hsin Yang} and Lin, {Chi Yao} and Liu, {Chia Hao} and Sun, {Pi Lin} and Twu, {Nae Fang} and Wu, {Hua Hsi} and Yu, {Hann Chin} and Ju, {Fong Yuan} and Tsai, {Chih Ping} and Chang, {Wen Hsun} and Hsu, {Yen Mei} and Lee, {Na Rong} and Chen, {Chih Yao} and Chang, {Ting Chen} and Chang, {Wen Chun} and Chen, {Chii Hou} and Chen, {Ruey Jian} and Chow, {Song Nan} and Lien, {Yih Ron} and Sheu, {Bor Ching} and Torng, {Pao Ling} and Yen, {Men Luh} and Lee, {Wen Ling} and Wang, {Kuan Chin} and Chang, {Chih Long} and Chen, {Chih Ping} and Chen, {Jen Ruei} and Chen, {Tze Chien} and Huang, {Jian Pei} and Huang, {Ming Chao} and Wang, {Yeou Lih} and Chang, {Cheng Chang} and Liu, {Jah Yao} and Su, {Her Young} and Wang, {Yu Chi} and Yu, {Mu Hsien} and Huang, {Lee Wen} and Seow, {Kok Min} and Lai, {Tsung Hsuan} and Lee, {Fa Kung} and Chen, {Ching Hui} and Huang, {Ben Shian} and Hsiao, {Sheng Mou} and Sun, {Hsu Dong} and Wu, {Wen Yih} and Teng, {Sen Wen} and Chen, {Kuo Hu} and Hung, {Jeng Hsiu} and Lai, {Hung Cheng} and Yuan, {Chiou Chung} and Hsieh, {Ching Hung} and Wang, {Chin Jung} and Chang, {Shing Jyh} and Hung, {Man Jung} and Hsu, {Shih Tien} and Ke, {Yu Min} and Lu, {Chien Hsing} and Lou Sun and Chang, {Wei Chun} and Hung, {Yao Ching} and Lin, {Wu Chou} and Wang, {Po Hui} and Chen, {Tze Ho} and Li, {Yiu Tai} and Wu, {Meng Hsing} and Huang, {Kuo Feng} and Fu, {Hung Chun} and Chen, {San Nung} and Chiang, {An Jen} and Li, {Ju Yueh} and Lin, {Li Te} and Tsai, {Hsiao Wen} and Tsui, {Kuan Hao}",
note = "Funding Information: This work was supported in part by a grant from the Ministry of Science and Technology, Executive Yuan ( MOST 103-2314-B-010-043-MY3 ), and by Taipei Veterans General Hospital ( V102C-141 , V103C-112 , V104C-095 , and V105C-096 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study. We also thank the Clinical Research Core Laboratory and the Medical Science & Technology Building of Taipei Veterans General Hospital for providing experimental space and facilities.",
year = "2016",
month = aug,
day = "1",
doi = "10.1016/j.tjog.2016.04.034",
language = "English",
volume = "55",
pages = "472--479",
journal = "Taiwanese Journal of Obstetrics and Gynecology",
issn = "1028-4559",
publisher = "臺灣婦產科醫學會",
number = "4",
}