TY - JOUR
T1 - Using submicroporous Ta oxide coatings deposited by a simple hydrolysis-condensation process to increase the biological responses to Ti surface
AU - Sun, Ying Sui
AU - Chang, Jean Heng
AU - Huang, Her Hsiung
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - This study used a simple hydrolysis-condensation process to prepare a tantalum pentoxide (Ta2O5) coating with submicroporous topography on a titanium (Ti) substrate. This coating is capable of enhancing biological responses. Characteristics of the surface coating, including morphology, composition, occurrence of functional groups, crystallographic structure, and degree of adherence, were analyzed. The release of Ti ions from the specimens in simulated blood plasma was also measured. The cytotoxicity of the specimens was determined according to ISO10993-5 specifications. We then evaluated biological responses, including fibronectin (FN) adsorption and human bone marrow mesenchymal stem cell (hBMSC) responses. Our results demonstrate that this simple hydrolysis-condensation process produced a negatively charged amorphous Ta2O5 coating with submicroporous topography and good adhesion to the Ti surface. Compared with an uncoated Ti surface, the Ta2O5 coating reduced the release of Ti ions and significantly enhanced FN adsorption and hBMSC responses, including cytoskeletal arrangement, cell adhesion, and cell proliferation. Thus, the proposed submicroporous Ta2O5 coating on a Ti surface has considerable potential for bone implant applications.
AB - This study used a simple hydrolysis-condensation process to prepare a tantalum pentoxide (Ta2O5) coating with submicroporous topography on a titanium (Ti) substrate. This coating is capable of enhancing biological responses. Characteristics of the surface coating, including morphology, composition, occurrence of functional groups, crystallographic structure, and degree of adherence, were analyzed. The release of Ti ions from the specimens in simulated blood plasma was also measured. The cytotoxicity of the specimens was determined according to ISO10993-5 specifications. We then evaluated biological responses, including fibronectin (FN) adsorption and human bone marrow mesenchymal stem cell (hBMSC) responses. Our results demonstrate that this simple hydrolysis-condensation process produced a negatively charged amorphous Ta2O5 coating with submicroporous topography and good adhesion to the Ti surface. Compared with an uncoated Ti surface, the Ta2O5 coating reduced the release of Ti ions and significantly enhanced FN adsorption and hBMSC responses, including cytoskeletal arrangement, cell adhesion, and cell proliferation. Thus, the proposed submicroporous Ta2O5 coating on a Ti surface has considerable potential for bone implant applications.
KW - Cell response
KW - Hydrolysis-condensation
KW - Submicroporous
KW - Tantalum pentoxide
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U2 - 10.1016/j.surfcoat.2014.03.033
DO - 10.1016/j.surfcoat.2014.03.033
M3 - Article
AN - SCOPUS:84923420802
SN - 0257-8972
VL - 259
SP - 199
EP - 205
JO - Surface and Coatings Technology
JF - Surface and Coatings Technology
IS - PB
ER -