摘要
Resistance of cancer cells to chemotherapy and/or radiotherapy is a major challenge to current anticancer treatment. The NF-κB signaling pathway plays an important role in tumor development and progression, and results in unsatisfactory treatment outcome. Inhibition of the NF-κB signaling cascade may sensitize the resistant cancer cells to chemotherapy and/or radiotherapy. Here, the correlation of NF-κB molecules with carcinogenesis and tumor progression, along with its significance in clinical practice, is reviewed. The potential clinical application of NF-κB and its associated molecules as diagnostic and therapeutic targets is also discussed.
原文 | 英語 |
---|---|
頁(從 - 到) | 139-146 |
頁數 | 8 |
期刊 | Expert Review of Molecular Diagnostics |
卷 | 12 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 3月 2012 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 分子醫學
- 分子生物學
- 遺傳學
- 病理學與法醫學