TY - JOUR
T1 - Usefulness of plasma YKL-40 in management of community-acquired pneumonia severity in patients
AU - Wang, Hsiang Ling
AU - Hsiao, Pei Ching
AU - Tsai, Hsiu Ting
AU - Yeh, Chao Bin
AU - Yang, Shun Fa
PY - 2013/11/19
Y1 - 2013/11/19
N2 - Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.
AB - Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.
KW - Community-acquired pneumonia
KW - Severity
KW - YKL-40
UR - http://www.scopus.com/inward/record.url?scp=84887933527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887933527&partnerID=8YFLogxK
U2 - 10.3390/ijms141122817
DO - 10.3390/ijms141122817
M3 - Article
C2 - 24256818
AN - SCOPUS:84887933527
SN - 1661-6596
VL - 14
SP - 22817
EP - 22825
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 11
ER -