Up-regulation of Na + expression in the area postrema of total sleep deprived rats by TOF-SIMS analysis

Fu Der Mai, Bo Jung Chen, Yong Chien Ling, Un In Wu, Yi Lun Huang, Hung Ming Chang

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3 引文 斯高帕斯(Scopus)


Area postrema (AP) is a circumventricular organ plays an important role in sodium homeostasis and cardiovascular regulation. Since sleep deficiency will cause cardiovascular dysfunction, the present study aims to determine whether sodium level would significantly alter in AP following total sleep deprivation (TSD). Sodium level was investigated in vivo by time-of-flight secondary ion mass spectrometry (TOF-SIMS). Clinical manifestation of cardiovascular function was demonstrated by mean arterial pressure (MAP) values. Results indicated that in normal rats, TOF-SIMS spectrum revealed a major peak of sodium ion counting as 5.61 × 105 at m/z 23. The sodium ions were homogeneous distributed in AP without specific localization. However, following TSD, the sodium intensity was relatively increased (6.73 × 105) and the signal for sodium image was strongly expressed throughout AP with definite spatial distribution. MAP of TSD rats is 138 ± 5 mmHg, which is significantly higher than that of normal ones (121 ± 3 mmHg). Regarding AP is an important area for sodium sensation and development of hypernatremic related sympatho-excitation; up-regulation of sodium expression following TSD suggests that high sodium level might over-activate AP, through complex neuronal networks involving in sympathetic regulation, which could lead to the formation of TSD relevant cardiovascular diseases.
頁(從 - 到)1135-1138
期刊Applied Surface Science
出版狀態已發佈 - 12月 15 2008

ASJC Scopus subject areas

  • 一般化學
  • 凝聚態物理學
  • 表面、塗料和薄膜
  • 一般物理與天文學
  • 表面和介面


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