摘要
BACKGROUND: Human papillomavirus (HPV) 16/18 infection is associated with nonsmoking lung cancer. In this study, the authors investigated a putative correlation between interleukin (IL)-17 expression and HPV infection in clinical nonsmall cell lung cancer (NSCLC) tissues and examined the effects of HPV infection on a human NSCLC cell line. METHODS: IL-17 expression was investigated in 79 NSCLC tumor tissues by immunohistochemistry. Growth rate, IL-17 mRNA, and secreting protein levels were also examined in HPV 16/18 E6-transfected H1299 human NSCLC cells. RESULTS: Immunohistochemical data showed that 48.1% of lung tumors had IL-17 staining, which was significantly associated with patients' sex (P=.03), HPV infection (P=.002), and tumor stage (P=.03). Significant correlations of IL-17 with IL-6 (P <.001) and IL-17 with Mcl-1 (P <.001) expression were also observed. Cell growth rate was increased, and IL-17/Mcl-1 expression levels were elevated in HPV 16 E6-transfected H1299 cells. The transfected E6 oncoproteins can significantly up-regulate expression levels of IL-17 and antiapoptotic protein Mcl-1. CONCLUSIONS: The study suggests that HPV infection-induced IL-17 levels can stimulate Mcl-1 expression through the PI3K pathway and promote lung tumor cell progression through a p53-and IL-6-independent pathway. © 2010 American Cancer Society.
原文 | 英語 |
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頁(從 - 到) | 4800-4809 |
頁數 | 10 |
期刊 | Cancer |
卷 | 116 |
發行號 | 20 |
DOIs | |
出版狀態 | 已發佈 - 2010 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 癌症研究
- 腫瘤科