TY - JOUR
T1 - Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
AU - Chang, Shu Chun
AU - Ding, Jeak Ling
N1 - Funding Information:
This work was jointly supported by the Ministry of Education ( R-154-000-A31-114 ), Singapore; the Ministry of Science and Technology, Taiwan ( MOST105-2320-B-038-007-MY2 , MOST107-2314-B-038-066 ); and Taipei Medical University ( TMU104-AE1-B104 ).
Funding Information:
This work was jointly supported by the Ministry of Education (R-154-000-A31-114), Singapore; the Ministry of Science and Technology, Taiwan (MOST105-2320-B-038-007-MY2, MOST107-2314-B-038-066); and Taipei Medical University (TMU104-AE1-B104).
Publisher Copyright:
© 2018 The Authors
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Cells and soluble mediators of the innate and adaptive immune systems are fundamental components of the tumor microenvironment. Nuclear factors, e.g. transcription factors (TFs) and oncoproteins/cancer suppressors, play important roles in controlling cytokine functions leading to the development, maintenance and metastasis of cancers. Studies focusing on the regulators of the pro-tumorigenic microenvironment are particularly pertinent to early diagnosis and potential development of targeted cancer therapeutics. This review is motivated by new insights into the molecular dynamics of ubiquitination and SUMOylation, which post-translationally modify tumor suppressor TFs, leading to initiation and progression of various cancers like prostate, colorectal, liver and breast cancers. These modification pathways are differentially modulated under various stimuli or stresses in order to sustain the oncogenic potentials. We deliberate on the vicious cycle of infection and chronic inflammation-driven processes of ubiquitination and SUMOylation, resulting in the imbalance in cytokine profiles in the pro-tumorigenic microenvironment.
AB - Cells and soluble mediators of the innate and adaptive immune systems are fundamental components of the tumor microenvironment. Nuclear factors, e.g. transcription factors (TFs) and oncoproteins/cancer suppressors, play important roles in controlling cytokine functions leading to the development, maintenance and metastasis of cancers. Studies focusing on the regulators of the pro-tumorigenic microenvironment are particularly pertinent to early diagnosis and potential development of targeted cancer therapeutics. This review is motivated by new insights into the molecular dynamics of ubiquitination and SUMOylation, which post-translationally modify tumor suppressor TFs, leading to initiation and progression of various cancers like prostate, colorectal, liver and breast cancers. These modification pathways are differentially modulated under various stimuli or stresses in order to sustain the oncogenic potentials. We deliberate on the vicious cycle of infection and chronic inflammation-driven processes of ubiquitination and SUMOylation, resulting in the imbalance in cytokine profiles in the pro-tumorigenic microenvironment.
KW - Cytokine profile
KW - Inflammation-associated cancer
KW - Small ubiquitin-like modifier (SUMO)
KW - Transcription factors
KW - Tumor microenvironment
KW - Ubiquitin-proteasome system (UPS)
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U2 - 10.1016/j.bbcan.2018.08.002
DO - 10.1016/j.bbcan.2018.08.002
M3 - Review article
AN - SCOPUS:85052649027
SN - 0304-419X
VL - 1870
SP - 165
EP - 175
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 2
ER -