摘要
Ubiquitin-like proteins (UBLs) are posttranslational modifiers with a structurally conserved β-grasp fold. These sequence-wise unrelated proteins share similar modification mechanism with ubiquitin and regulate every facet of eukaryote life. With rapidly advancing proteomic techniques, it is now possible to systemically decode UBL modification on protein functions. In this article, we first cover basic biochemical principles of UBL cycling. Then, a brief review of biological implications on several well-characterized UBLs (small ubiquitin-like modifiers (SUMOs), neural precursor cell expressed, developmentally down regulated 8 (NEDD8), interferon-induced 15-kDa protein (Isg15), Atg8, Atg12, and Fat10) is provided.
| 原文 | 英語 |
|---|---|
| 主出版物標題 | Encyclopedia of Biological Chemistry |
| 主出版物子標題 | Second Edition |
| 發行者 | Elsevier Inc. |
| 頁面 | 467-472 |
| 頁數 | 6 |
| ISBN（電子） | 9780123786319 |
| ISBN（列印） | 9780123786302 |
| DOIs | |
| 出版狀態 | 已發佈 - 2月 15 2013 |
| 對外發佈 | 是 |
Keywords
- ATG12
- ATG8
- Cullins
- FAT10
- Interferon-induced 15-kDa protein (ISG15)
- Neural precursor cell expressed, developmentally down regulated 8 (NEDD8)
- Small ubiquitin-like modifier (SUMO)
- Ubiquitin-like proteins (UBL)
- UBL-binding domain
ASJC Scopus subject areas
- 一般生物化學，遺傳學和分子生物學