@article{818ad964c7d24f828b9c1a262cc67875,
title = "Type-3 hyaluronan synthase attenuates tumor cells invasion in human mammary parenchymal tissues",
abstract = "The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular matrix can attenuate the invasion of human breast tumor cells. Decreased HA levels in subcutaneous Has3-KO mouse tissues promoted orthotopic breast cancer (E0771) cell-derived allograft tumor growth. MDA-MB-231 cells premixed with higher concentration HA attenuate tumor growth in xenografted nude mice. Human patient-derived xenotransplantation (PDX) experiments found that HA selected the highly migratory breast cancer cells with CD44 expression accumulated in the tumor/stroma junc-tion. In conclusion, HAS3 and HA were detected in the stroma breast tissues at a high level attenuates effects for induced breast cancer cell death, and inhibit the cancer cells invasion at the initial stage. However, the highly migratory cancer cells were resistant to the HA-mediated effects with unknown mechanisms.",
keywords = "Au-tophagy, Breast cancer, Hyaluronan synthase 3, Tubulin acetylation, Tumor microenvironment",
author = "Lee, {Wen Jui} and Tu, {Shih Hsin} and Cheng, {Tzu Chun} and Lin, {Juo Han} and Sheu, {Ming Thau} and Kuo, {Ching Chuan} and Changou, {Chun A.} and Wu, {Chih Hsiung} and Chang, {Hui Wen} and Chang, {Hang Lung} and Chen, {Li Ching} and Ho, {Yuan Soon}",
note = "Funding Information: Funding: This study was supported by a Health and Welfare Surcharge on Tobacco Products grant (MOHW110-TDU-B-212-144014); the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan; and the Ministry of Science and Technology, Taiwan (MOST108-2320-B-038-033-MY3 and MOST110-2320-B-038-082 awarded to Ho, MOST109-2314-B-038-033-MY3 awarded to Tu, MOST110-2320-B-038-031 awarded to Chen). This work was supported by the Zhejiang Innovation Discipline Project of Laboratory Animal Genetic Engineering (No. 201604). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = nov,
day = "1",
doi = "10.3390/molecules26216548",
language = "English",
volume = "26",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "21",
}
