Tumor induction by direct injection of cloned v-src DNA into chickens

Y. K T Fung, L. B. Crittenden, A. M. Fadly, H. J. Kung

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53 引文 斯高帕斯(Scopus)


The in vitro transforming potential of Rous sarcoma viruses has been shown to reside in a gene segment, v-src. To provide direct proof that the isolated v-src sequence contains all the information necessary for sarcoma induction in vivo, we have injected subgenomic and genomic cloned DNA carrying v-src directly into chickens. We report that v-src, without the complements of other viral genes, can effectively induce sarcomas in the host within weeks after injection. The sarcoma tumors generated by subgenomic v-src DNA are of mono- or oligoclonal origin. They have acquired v-src sequences in the genome and expressed high levels of src messages. Intact long terminal repeats do not seem to be essential in the tumorigenic process.
頁(從 - 到)353-357
期刊Proceedings of the National Academy of Sciences of the United States of America
發行號2 I
出版狀態已發佈 - 1月 1 1983

ASJC Scopus subject areas

  • 多學科
  • 遺傳學


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