Trilinolein improves erythrocyte deformability during cardiopulmonary bypass

S. K. Tsai, P. Chan, T. Y. Lee, J. M. Yung, C. Y. Hong

研究成果: 雜誌貢獻文章同行評審

21 引文 斯高帕斯(Scopus)


The in vitro effect of trilinolein, a triglyceride with linoleic acid as the major fatty acid residue in the esterified positions of glycerol, on erythrocyte deformability was studied in blood samples collected from 12 patients before and after cardiopulmonary bypass (CPB). Erythrocyte deformability was measured with a filtration method and expressed as red cell filtration rate (RFR). RFR was reduced after CPB and the reduction was time dependent. Trilinolein at a concentration of 10-7 M significantly reversed the CPB-induced reduction of RFR when it was mixed with blood samples collected 30, 60 and 90 min from the start of CPB. This study confirmed the effect of CPB on erythrocyte deformability and showed that this damage could be significantly improved by mixing blood with trilinolein.

頁(從 - 到)457-459
期刊British Journal of Clinical Pharmacology
出版狀態已發佈 - 1994

ASJC Scopus subject areas

  • 藥學(醫學)
  • 藥理學、毒理學和藥劑學 (全部)


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