Tribological process induced conformational transformation of protein may change the friction of cartilage

Chih Hung Chang; Hsu Wei Fang; Huei Ting Huang; Hsuan Liang Liu; Wei Ming Lee; Man Ching Hsieh; Chiang San Chen

doi:10.1016/j.matlet.2006.11.077

Tribological process induced conformational transformation of protein may change the friction of cartilage

Chih Hung Chang, Hsu Wei Fang, Huei Ting Huang, Hsuan Liang Liu, Wei Ming Lee, Man Ching Hsieh, Chiang San Chen

研究成果: 雜誌貢獻 › 文章 › 同行評審

5 引文斯高帕斯（Scopus）

摘要

In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.

原文	英語
頁（從 - 到）	3381-3384
頁數	4
期刊	Materials Letters
卷	61
發行號	16
DOIs	https://doi.org/10.1016/j.matlet.2006.11.077
出版狀態	已發佈 - 6月 1 2007
對外發佈	是

ASJC Scopus subject areas

一般材料科學
凝聚態物理學
材料力學
機械工業

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10.1016/j.matlet.2006.11.077

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title = "Tribological process induced conformational transformation of protein may change the friction of cartilage",

abstract = "In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.",

keywords = "Albumin, Cartilage, Friction, Partial joint arthroplasty, Tribochemistry, UHMWPE",

author = "Chang, {Chih Hung} and Fang, {Hsu Wei} and Huang, {Huei Ting} and Liu, {Hsuan Liang} and Lee, {Wei Ming} and Hsieh, {Man Ching} and Chen, {Chiang San}",

note = "Funding Information: The authors are pleased to acknowledge the financial support from the US Air Force (AOARD-05-4081) and the Far Eastern Memorial Hospital (FEMH-94-C-040), Taiwan.",

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AU - Chang, Chih Hung

AU - Fang, Hsu Wei

AU - Huang, Huei Ting

AU - Liu, Hsuan Liang

AU - Lee, Wei Ming

AU - Hsieh, Man Ching

AU - Chen, Chiang San

N1 - Funding Information: The authors are pleased to acknowledge the financial support from the US Air Force (AOARD-05-4081) and the Far Eastern Memorial Hospital (FEMH-94-C-040), Taiwan.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.

AB - In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.

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KW - Partial joint arthroplasty

KW - Tribochemistry

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Tribological process induced conformational transformation of protein may change the friction of cartilage

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