TY - JOUR
T1 - Trends of Gold Nanoparticle-based Drug Delivery System in Cancer Therapy
AU - Ajnai, Giimel
AU - Chiu, Amy
AU - Kan, Tzuchun
AU - Cheng, Chun Chia
AU - Tsai, Teh Hua
AU - Chang, Jungshan
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Following surgical removal of malignant tumors, chemotherapeutic intervention usually is subsequently applied in patients with advanced stages of cancer. Most chemotherapeutic drugs are intravenously injected into patients, leading to systemic cytotoxicity in organs and tissues, including healthy tissue and tumors. Currently, it has been demonstrated that gold nanoparticles can easily penetrate blood vessels and tissue barriers into tumor foci, which indicates gold nanoparticles as a more effective drug carrier with great merits in reducing cytotoxicity and economic burden in patients. Moreover, gold nanoparticles display several unique characterizations with multiple functions in therapeutics, imaging, and surface modification, suggesting gold nanoparticles may become effective antitumor drug carriers. In this review article, we discuss the limitations and applications of gold nanoparticles in surface modification, targeting strategy, and safety considerations.
AB - Following surgical removal of malignant tumors, chemotherapeutic intervention usually is subsequently applied in patients with advanced stages of cancer. Most chemotherapeutic drugs are intravenously injected into patients, leading to systemic cytotoxicity in organs and tissues, including healthy tissue and tumors. Currently, it has been demonstrated that gold nanoparticles can easily penetrate blood vessels and tissue barriers into tumor foci, which indicates gold nanoparticles as a more effective drug carrier with great merits in reducing cytotoxicity and economic burden in patients. Moreover, gold nanoparticles display several unique characterizations with multiple functions in therapeutics, imaging, and surface modification, suggesting gold nanoparticles may become effective antitumor drug carriers. In this review article, we discuss the limitations and applications of gold nanoparticles in surface modification, targeting strategy, and safety considerations.
KW - Gold nanoparticles
KW - Nanomedicine
KW - Reticuloendothelial system
UR - http://www.scopus.com/inward/record.url?scp=84916224668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84916224668&partnerID=8YFLogxK
U2 - 10.1016/j.jecm.2014.10.015
DO - 10.1016/j.jecm.2014.10.015
M3 - Article
AN - SCOPUS:84916224668
SN - 1878-3317
VL - 6
SP - 172
EP - 178
JO - Journal of Experimental and Clinical Medicine(Taiwan)
JF - Journal of Experimental and Clinical Medicine(Taiwan)
IS - 6
ER -
