Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Ren Kuo Lin; Chia Wen Ho; Leroy-Fong Liu; Yi Lisa Lyu

doi:10.1074/jbc.M112.415471

Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Ren Kuo Lin, Chia Wen Ho, Leroy-Fong Liu, Yi Lisa Lyu

研究成果: 雜誌貢獻 › 文章 › 同行評審

7 引文斯高帕斯（Scopus）

摘要

Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.

原文	英語
頁（從 - 到）	7182-7192
頁數	11
期刊	Journal of Biological Chemistry
卷	288
發行號	10
DOIs	https://doi.org/10.1074/jbc.M112.415471
出版狀態	已發佈 - 3月 8 2013
對外發佈	是

ASJC Scopus subject areas

生物化學
細胞生物學
分子生物學

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10.1074/jbc.M112.415471

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abstract = "Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.",

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AU - Ho, Chia Wen

AU - Liu, Leroy-Fong

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AB - Background: The sensitivity of non-S-phase cells to Top1-targeting drugs has been under-explored. Results: Quiescent Top2β-deficient cells are specifically hypersensitive to Top1-targeting drugs. Conclusion: Top2α deficiency promotes camptothecin-induced apoptosis as a result of RNA polymerase II depletion and p53 accumulation. Significance: This study has identified Top2α as a novel determinant for camptothecin sensitivity.

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Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

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