TY - JOUR
T1 - Three New Oleanane-Type Triterpenes from Ludwigia octovalvis with Cytotoxic Activity against Two Human Cancer Cell Lines
AU - Chang, Chi I.
AU - Kuo, Ching Chuan
AU - Chang, Jang Yang
AU - Kuo, Yueh Hsiung
PY - 2004/1
Y1 - 2004/1
N2 - Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC50 values in the range 1.2-3.6 μM.
AB - Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC50 values in the range 1.2-3.6 μM.
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U2 - 10.1021/np030267m
DO - 10.1021/np030267m
M3 - Article
C2 - 14738395
AN - SCOPUS:0942269005
SN - 0163-3864
VL - 67
SP - 91
EP - 93
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 1
ER -
