Therapeutic applications of resveratrol and its derivatives on periodontitis

Yu Tang Chin, Guei Yun Cheng, Ya Jung Shih, Chi Yu Lin, Shan Jen Lin, Hsuan Yu Lai, Jacqueline Whang-Peng, Hsien Chung Chiu, Sheng Yang Lee, Earl Fu, Heng Yuan Tang, Hung Yun Lin, Leroy F. Liu

研究成果: 雜誌貢獻回顧型文獻同行評審

39 引文 斯高帕斯(Scopus)


Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time-consuming. Recently, herbal medicines have been considered for use in treating inflammation-related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti-inflammatory properties and other medical benefits. Here, we highlight the importance of resveratrol and its glycosylated derivative as possible complementary treatments for periodontitis and their potential for development as innovative therapeutic strategies. In addition, we present evidence and discuss the mechanisms of action of resveratrol and THSG on periodontitis, focusing on Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. We also illuminate the signal transduction pathways and the cytokines involved.
頁(從 - 到)101-108
期刊Annals of the New York Academy of Sciences
出版狀態已發佈 - 9月 1 2017

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)
  • 科學史與哲學


深入研究「Therapeutic applications of resveratrol and its derivatives on periodontitis」主題。共同形成了獨特的指紋。