TY - JOUR
T1 - Theranostic doxorubicin encapsulated FeAu alloy@metal-organic framework nanostructures enable magnetic hyperthermia and medical imaging in oral carcinoma
AU - Dhawan, Udesh
AU - Tseng, Ching Li
AU - Wu, Ping Hsuan
AU - Liao, Mei Yi
AU - Wang, Huey Yuan
AU - Wu, Kevin C.W.
AU - Chung, Ren Jei
N1 - Funding Information:
The authors are grateful for the financial supports of this research by the Ministry of Science and Technology of Taiwan (MOST 108-2628-E-027-003-MY3; MOST 111-2221-E-027-105), the National Taipei University of Technology-Mackay Memorial Hospital Joint Research Program (NTUT-MMH-108-08, NTUT-MMH-109-04, NTUT-MMH-111-01).
Funding Information:
The authors are grateful for the financial supports of this research by the Ministry of Science and Technology of Taiwan (MOST 108-2628-E-027-003-MY3 ; MOST 111-2221-E-027-105 ), the National Taipei University of Technology - Mackay Memorial Hospital Joint Research Program ( NTUT-MMH-108-08 , NTUT-MMH-109-04 , NTUT-MMH-111-01).
Publisher Copyright:
© 2023
PY - 2023/2
Y1 - 2023/2
N2 - Metal-organic frameworks (MOFs) have emerged as attractive candidates in cancer theranostics due to their ability to envelop magnetic nanoparticles, resulting in reduced cytotoxicity and high porosity, enabling chemodrug encapsulation. Here, FeAu alloy nanoparticles (FeAu NPs) are synthesized and coated with MIL-100(Fe) MOFs to fabricate FeAu@MOF nanostructures. We encapsulated Doxorubicin within the nanostructures and evaluated the suitability of this platform for medical imaging and cancer theranostics. FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited superparamagnetism, magnetic hyperthermia behavior and displayed DOX encapsulation and release efficiency of 69.95 % and 97.19 %, respectively, when stimulated with alternating magnetic field (AMF). In-vitro experiments showed that AMF-induced hyperthermia resulted in 90 % HSC-3 oral squamous carcinoma cell death, indicating application in cancer theranostics. Finally, in an in-vivo mouse model, FeAu@MOF nanostructures improved image contrast, reduced tumor volume by 30-fold and tumor weight by 10-fold, which translated to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment.
AB - Metal-organic frameworks (MOFs) have emerged as attractive candidates in cancer theranostics due to their ability to envelop magnetic nanoparticles, resulting in reduced cytotoxicity and high porosity, enabling chemodrug encapsulation. Here, FeAu alloy nanoparticles (FeAu NPs) are synthesized and coated with MIL-100(Fe) MOFs to fabricate FeAu@MOF nanostructures. We encapsulated Doxorubicin within the nanostructures and evaluated the suitability of this platform for medical imaging and cancer theranostics. FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited superparamagnetism, magnetic hyperthermia behavior and displayed DOX encapsulation and release efficiency of 69.95 % and 97.19 %, respectively, when stimulated with alternating magnetic field (AMF). In-vitro experiments showed that AMF-induced hyperthermia resulted in 90 % HSC-3 oral squamous carcinoma cell death, indicating application in cancer theranostics. Finally, in an in-vivo mouse model, FeAu@MOF nanostructures improved image contrast, reduced tumor volume by 30-fold and tumor weight by 10-fold, which translated to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment.
KW - cancer theranostics
KW - Hyperthermia
KW - iron‑gold alloy nanoparticles
KW - Metal-organic framework
KW - Oral squamous carcinoma
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U2 - 10.1016/j.nano.2023.102652
DO - 10.1016/j.nano.2023.102652
M3 - Article
C2 - 36623714
AN - SCOPUS:85147090761
SN - 1549-9634
VL - 48
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
M1 - 102652
ER -
