The variant mRNA isoform of human metastasis gene (CD44V) detected in the cell lines of human hepatocellular carcinoma

H. J. Harn; L. I. Ho; C. P. Yu; M. W. Wang; H. S. Lee; J. J. Lin; W. H. Lee; N. R. Isola; D. L. Cooper

The variant mRNA isoform of human metastasis gene (CD44V) detected in the cell lines of human hepatocellular carcinoma

H. J. Harn, L. I. Ho, C. P. Yu, M. W. Wang, H. S. Lee, J. J. Lin, W. H. Lee, N. R. Isola, D. L. Cooper

研究成果: 雜誌貢獻 › 文章 › 同行評審

摘要

The interaction of the cell surface receptor CD44 molecular with its ligands (addressin, extracellular matrix etc.,) plays an important role in fulfilling the lymphocyte homing and immune reaction. Recently alternatively spliced products of CD44 gene are found to be involved in tumor metastasis as well. Our report found that CD44 prototype RNA (CD44S) was present in all five tumor cell lines. Isoform CD44 RNA (CD44V) was recognized in three metastasized hepatocellular carcinoma cell lines, J5, HCC36, HEP38. In addition, the J5 CD44 RNA isoform expressed two distinct trancripts which are of the same size as MDA-231 breast tumor cell line. The MDA-231 CD44 RNA variant (CD44V) has been confirmed to contain metastasis domain 4 and 5. it is implicated that the alternative RNA splicing may also play a major role in hepatocellular carcinoma metastasis.

原文	英語
頁（從 - 到）	233-238
頁數	6
期刊	Biochemistry and Molecular Biology International
卷	32
發行號	2
出版狀態	已發佈 - 1994
對外發佈	是

ASJC Scopus subject areas

生物化學
遺傳學
分子生物學

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引用此

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title = "The variant mRNA isoform of human metastasis gene (CD44V) detected in the cell lines of human hepatocellular carcinoma",

abstract = "The interaction of the cell surface receptor CD44 molecular with its ligands (addressin, extracellular matrix etc.,) plays an important role in fulfilling the lymphocyte homing and immune reaction. Recently alternatively spliced products of CD44 gene are found to be involved in tumor metastasis as well. Our report found that CD44 prototype RNA (CD44S) was present in all five tumor cell lines. Isoform CD44 RNA (CD44V) was recognized in three metastasized hepatocellular carcinoma cell lines, J5, HCC36, HEP38. In addition, the J5 CD44 RNA isoform expressed two distinct trancripts which are of the same size as MDA-231 breast tumor cell line. The MDA-231 CD44 RNA variant (CD44V) has been confirmed to contain metastasis domain 4 and 5. it is implicated that the alternative RNA splicing may also play a major role in hepatocellular carcinoma metastasis.",

author = "Harn, {H. J.} and Ho, {L. I.} and Yu, {C. P.} and Wang, {M. W.} and Lee, {H. S.} and Lin, {J. J.} and Lee, {W. H.} and Isola, {N. R.} and Cooper, {D. L.}",

year = "1994",

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journal = "Biochemistry and Molecular Biology International",

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T1 - The variant mRNA isoform of human metastasis gene (CD44V) detected in the cell lines of human hepatocellular carcinoma

AU - Harn, H. J.

AU - Ho, L. I.

AU - Yu, C. P.

AU - Wang, M. W.

AU - Lee, H. S.

AU - Lin, J. J.

AU - Lee, W. H.

AU - Isola, N. R.

AU - Cooper, D. L.

PY - 1994

Y1 - 1994

N2 - The interaction of the cell surface receptor CD44 molecular with its ligands (addressin, extracellular matrix etc.,) plays an important role in fulfilling the lymphocyte homing and immune reaction. Recently alternatively spliced products of CD44 gene are found to be involved in tumor metastasis as well. Our report found that CD44 prototype RNA (CD44S) was present in all five tumor cell lines. Isoform CD44 RNA (CD44V) was recognized in three metastasized hepatocellular carcinoma cell lines, J5, HCC36, HEP38. In addition, the J5 CD44 RNA isoform expressed two distinct trancripts which are of the same size as MDA-231 breast tumor cell line. The MDA-231 CD44 RNA variant (CD44V) has been confirmed to contain metastasis domain 4 and 5. it is implicated that the alternative RNA splicing may also play a major role in hepatocellular carcinoma metastasis.

AB - The interaction of the cell surface receptor CD44 molecular with its ligands (addressin, extracellular matrix etc.,) plays an important role in fulfilling the lymphocyte homing and immune reaction. Recently alternatively spliced products of CD44 gene are found to be involved in tumor metastasis as well. Our report found that CD44 prototype RNA (CD44S) was present in all five tumor cell lines. Isoform CD44 RNA (CD44V) was recognized in three metastasized hepatocellular carcinoma cell lines, J5, HCC36, HEP38. In addition, the J5 CD44 RNA isoform expressed two distinct trancripts which are of the same size as MDA-231 breast tumor cell line. The MDA-231 CD44 RNA variant (CD44V) has been confirmed to contain metastasis domain 4 and 5. it is implicated that the alternative RNA splicing may also play a major role in hepatocellular carcinoma metastasis.

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The variant mRNA isoform of human metastasis gene (CD44V) detected in the cell lines of human hepatocellular carcinoma

摘要

ASJC Scopus subject areas

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