The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Chun Han Ho; Hao Ching Wang; Tzu Ping Ko; Yuan Chih Chang; Andrew H J Wang

doi:10.1074/jbc.M114.590851

The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Chun Han Ho
, Hao Ching Wang
, Tzu Ping Ko
, Yuan Chih Chang
, Andrew H J Wang

研究成果: 雜誌貢獻 › 文章 › 同行評審

33 引文斯高帕斯（Scopus）

摘要

Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.

Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.

Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.

Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.

原文	英語
頁（從 - 到）	27046-27054
頁數	9
期刊	Journal of Biological Chemistry
卷	289
發行號	39
DOIs	https://doi.org/10.1074/jbc.M114.590851
出版狀態	已發佈 - 9月 26 2014

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 良好的健康和福祉

ASJC Scopus subject areas

生物化學
分子生物學
細胞生物學

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10.1074/jbc.M114.590851

其它文件與鏈接

Link to publication in Scopus

3WX4 : CRYSTAL STRUCTURE of T4 PHAGE ARN PROTEIN
Ho, C.-H. (Contributor), Wang, H.-C. (Contributor), Ko, T.-P. (Contributor) & Wang, A.H.-J. (Contributor), RCSB-PDB, 2014
DOI: 10.2210/pdb3wx4/pdb, https://www.rcsb.org/structure/3WX4
資料集: Dataset

引用此

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abstract = "Background: DNA mimic proteins prevent DNA-binding proteins from binding to DNA.Results: T4 phage DNA mimic protein Arn disrupts H-NS·DNA binding and neutralizes the gene-silencing effect of H-NS.Conclusion: Arn participates in viral anti-host defense system by its DNA mimicking properties.Significance: This anti-H-NS function of Arn represents a novel battle mechanism between phage and bacteria.",

author = "Ho, \{Chun Han\} and Wang, \{Hao Ching\} and Ko, \{Tzu Ping\} and Chang, \{Yuan Chih\} and Wang, \{Andrew H J\}",

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AU - Chang, Yuan Chih

AU - Wang, Andrew H J

PY - 2014/9/26

Y1 - 2014/9/26

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ER -

The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

摘要

UN SDG

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

3WX4 : CRYSTAL STRUCTURE of T4 PHAGE ARN PROTEIN

引用此