The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease

Kang-Wei Chang; C. C. Chen; S. Y. Lee; L. H. Shen; H. E. Wang

doi:10.1016/j.apradiso.2009.02.039

The synthesis and characterization of [¹²⁴I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease

Kang-Wei Chang, C. C. Chen, S. Y. Lee, L. H. Shen, H. E. Wang

研究成果: 雜誌貢獻 › 文章 › 同行評審

3 引文斯高帕斯（Scopus）

摘要

6-[124I]iodo-2-(4′-N,N-dimethylamino)-phenylimidazo[1,2 -a]pyridine ([124I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [124I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.

原文	英語
頁（從 - 到）	1397-1400
頁數	4
期刊	Applied Radiation and Isotopes
卷	67
發行號	7-8
DOIs	https://doi.org/10.1016/j.apradiso.2009.02.039
出版狀態	已發佈 - 7月 1 2009

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10.1016/j.apradiso.2009.02.039

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abstract = "6-[124I]iodo-2-(4′-N,N-dimethylamino)-phenylimidazo[1,2 -a]pyridine ([124I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [124I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.",

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AU - Wang, H. E.

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