The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not

Keertan Dheda, Jung Su Chang, Jim F. Huggett, Louise U. Kim, Margaret A. Johnson, Alimuddin Zumla, Graham A W Rook

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

The prototype Th2 cytokine IL-4, and its competitive antagonist IL-4δ2, may be important determinants of outcome in human tuberculosis (TB). However, there are no data on how gene expression of these cytokines is regulated. To evaluate this the stability of IL-4 and IL-4δ2 mRNA after the addition of actinomycin-D, was evaluated in whole blood from subjects with pulmonary TB and uninfected healthy volunteers. The Th2/Th1 (IL-4/IFN-γ) mRNA ratio in unstimulated cells in whole blood was significantly greater in TB subjects than in controls (p

原文英語
頁(從 - 到)237-241
頁數5
期刊Tuberculosis
87
發行號3
DOIs
出版狀態已發佈 - 5月 2007
對外發佈

ASJC Scopus subject areas

  • 應用微生物與生物技術
  • 微生物學
  • 免疫學和過敏
  • 傳染性疾病
  • 獸醫 (全部)

指紋

深入研究「The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not」主題。共同形成了獨特的指紋。

引用此