The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not

Keertan Dheda; Jung Su Chang; Jim F. Huggett; Louise U. Kim; Margaret A. Johnson; Alimuddin Zumla; Graham A W Rook

doi:10.1016/j.tube.2006.11.001

The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not

Keertan Dheda, Jung Su Chang, Jim F. Huggett, Louise U. Kim, Margaret A. Johnson, Alimuddin Zumla, Graham A W Rook

研究成果: 雜誌貢獻 › 文章 › 同行評審

17 引文斯高帕斯（Scopus）

摘要

The prototype Th2 cytokine IL-4, and its competitive antagonist IL-4δ2, may be important determinants of outcome in human tuberculosis (TB). However, there are no data on how gene expression of these cytokines is regulated. To evaluate this the stability of IL-4 and IL-4δ2 mRNA after the addition of actinomycin-D, was evaluated in whole blood from subjects with pulmonary TB and uninfected healthy volunteers. The Th2/Th1 (IL-4/IFN-γ) mRNA ratio in unstimulated cells in whole blood was significantly greater in TB subjects than in controls (p

原文	英語
頁（從 - 到）	237-241
頁數	5
期刊	Tuberculosis
卷	87
發行號	3
DOIs	https://doi.org/10.1016/j.tube.2006.11.001
出版狀態	已發佈 - 5月 2007
對外發佈	是

ASJC Scopus subject areas

應用微生物與生物技術
微生物學
免疫學和過敏
傳染性疾病
獸醫 (全部)

UN SDG

此研究成果有助於以下永續發展目標

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10.1016/j.tube.2006.11.001

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引用此

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abstract = "The prototype Th2 cytokine IL-4, and its competitive antagonist IL-4δ2, may be important determinants of outcome in human tuberculosis (TB). However, there are no data on how gene expression of these cytokines is regulated. To evaluate this the stability of IL-4 and IL-4δ2 mRNA after the addition of actinomycin-D, was evaluated in whole blood from subjects with pulmonary TB and uninfected healthy volunteers. The Th2/Th1 (IL-4/IFN-γ) mRNA ratio in unstimulated cells in whole blood was significantly greater in TB subjects than in controls (p",

keywords = "Half-life, Human, IL-4, IL-4δ2, mRNA, Tuberculosis",

author = "Keertan Dheda and Chang, {Jung Su} and Huggett, {Jim F.} and Kim, {Louise U.} and Johnson, {Margaret A.} and Alimuddin Zumla and Rook, {Graham A W}",

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AU - Huggett, Jim F.

AU - Kim, Louise U.

AU - Johnson, Margaret A.

AU - Zumla, Alimuddin

AU - Rook, Graham A W

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The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not

摘要

ASJC Scopus subject areas

UN SDG

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