TY - CHAP
T1 - The role of store-operated calcium channel in chronic inflammation
AU - Yang, Sheng Yu
AU - Chang, Wei Chiao
PY - 2013
Y1 - 2013
N2 - Calcium is an important second arymessenger that regulates a variety of physiological functions, including cell proliferation, enzyme metabolism, gene expression and apoptosis. In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and cancer cells, the predominant mechanism for calcium(Ca2+) entry is through store-operated Ca2+ channels (SOCs),which are activated by the emptying of intracellular Ca2+ stores. Here, we review some of the proposed gating mechanisms of store-operated Ca2+ channel and the functional implications of SOCs in the regulation of pro-inflammatory signals and tumor progression.
AB - Calcium is an important second arymessenger that regulates a variety of physiological functions, including cell proliferation, enzyme metabolism, gene expression and apoptosis. In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and cancer cells, the predominant mechanism for calcium(Ca2+) entry is through store-operated Ca2+ channels (SOCs),which are activated by the emptying of intracellular Ca2+ stores. Here, we review some of the proposed gating mechanisms of store-operated Ca2+ channel and the functional implications of SOCs in the regulation of pro-inflammatory signals and tumor progression.
UR - http://www.scopus.com/inward/record.url?scp=84892117086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892117086&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:84892117086
SN - 9781628080940
SP - 1
EP - 18
BT - Chronic Inflammation: Causes, Treatment Options and Role in Disease
PB - Nova Science Publishers, Inc.
ER -
