The successful operation of medical tourism mobile applications primarily depends on the extent to which users are fully motivated to adopt their use. Therefore, the primary purpose of this study was to investigate the factors influencing medical tourism mobile application usage intentions. This study applied the unified theory of acceptance and use of technology (UTAUT2) to build a comprehensive model that explains users’ intentions to use medical tourism mobile apps. Our research findings confirm the validity of the UTAUT2 in explaining users’ intentions to use medical tourism mobile apps in the context of medical tourism mobile services. Additionally, the results focus on the enhancement in the role of the other rather that contextual attributes of the IT/IS environment (i.e., personal involvement and personal innovativeness). This study can confirm the importance of the UTAUT2 constructs in the setting of medical tourism mobile app usage. By conducting surveys, medical tourism mobile app designers can know that personal involvement and personal innovativeness lead to influences on the effectiveness of corporate marketing efforts relating to using mobile medical apps.