The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders

Ram Sharma, Sachin Sharma, Amandeep Thakur, Arshdeep Singh, Jagjeet Singh, Kunal Nepali, Jing Ping Liou

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Epigenetic mutations like aberrant DNA methylation, histone modifications, or RNA silencing are found in a number of human diseases. This review article discusses the epigenetic mechanisms involved in neurodegenerative disorders, cardiovascular disorders, auto-immune disorders and genomic imprinting disorders. In addition, emerging epigenetic therapeutic strategies for the treatment of such disorders are presented. Medicinal chemistry campaigns highlighting the efforts of the chem-ists invested towards the rational design of small molecule inhibitors have also been included. Pleas-ingly, several classes of epigenetic inhibitors, DNMT, HDAC, BET, HAT, and HMT inhibitors, along with RNA based therapies, have exhibited the potential to emerge as therapeutics in the longer run. It is quite hopeful that epigenetic modulator-based therapies will advance to clinical stage investigations by leaps and bounds.
原文英語
頁(從 - 到)1977-2011
頁數35
期刊Mini-Reviews in Medicinal Chemistry
22
發行號15
DOIs
出版狀態已發佈 - 8月 2022

ASJC Scopus subject areas

  • 藥理
  • 藥物發現

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