@article{d06b5c92547840bc99a043790f1ff3c2,
title = "The relation between NEAT1 expression level and survival rate in patients with oral squamous cell carcinoma",
abstract = "Background/purpose: Numerous studies have shown that long noncoding RNAs (lncRNAs) are involved in cancer progression and chemotherapy resistance. Nuclear enriched abundant transcript 1 (NEAT1) is an lncRNA. It affects tumor cell progression and drug resistance in various tumors. However, the relation of NEAT1 and survival rate in oral squamous cell carcinoma (OSCC) requires further study. Materials and methods: One normal gingival epithelium cell line, SG, three oral cancer cell lines (HSC3, OEC-M1, and SAS), 34 paired non-cancerous matched tissues (NCMT), and OSCC tissues were used in this study. Tri-reagent was used for total RNA extraction. NEAT1 expression was assessed by reverse transcription-quantitative PCR (RT-qPCR). Results: NEAT1 expression in oral cancer cell lines was lower than that in normal cells and was significantly downregulated in OSCC. NEAT1 upregulation reduced the survival rate of patients with OSCC. NEAT1 upregulation also reduced the survival rate of OSCC patients treated with chemotherapy and radiotherapy. Conclusion: These results indicate that NEAT1 expression is a valuable biomarker for the prediction and prognosis of oral cancer.",
keywords = "Chemotherapy, Nuclear enriched abundant transcript 1 (NEAT1), Oral squamous cell carcinoma, Radiotherapy, Survival rate",
author = "Lin, {Nan Chin} and Hsia, {Shih Min} and Wang, {Tong Hong} and Li, {Po Jung} and Tseng, {Yu Hsin} and Chiu, {Kuo Chou} and Tu, {Hsi Feng} and Shih, {Yin Hwa} and Shieh, {Tzong Ming}",
note = "Funding Information: Experiments and data analysis were performed in part through the use of the Medical Research Core Facilities Center, Office of Research & Development at China medical University, Taichung, Taiwan, R.O.C. This study was supported by grants from China Medical University ( CMU109-S-17 , CMU109-MF-32 ) and the Ministry of Science and Technology , R.O.C. ( MOST 108-2314-B-039-009-MY3 ). Funding Information: Experiments and data analysis were performed in part through the use of the Medical Research Core Facilities Center, Office of Research & Development at China medical University, Taichung, Taiwan, R.O.C. This study was supported by grants from China Medical University (CMU109-S-17, CMU109-MF-32) and the Ministry of Science and Technology, R.O.C. (MOST 108-2314-B-039-009-MY3). Publisher Copyright: {\textcopyright} 2021 Association for Dental Sciences of the Republic of China",
year = "2022",
month = jan,
doi = "10.1016/j.jds.2021.09.018",
language = "English",
volume = "17",
pages = "361--367",
journal = "Journal of Dental Sciences",
issn = "1991-7902",
publisher = "中華牙醫學會",
number = "1",
}
