TY - JOUR
T1 - The Real- world Experience of Product- switching, Pharmacokinetics and Adherence of rFVIII- Fc in Patients with Hemophilia A：The Preliminary Report in Taiwan
AU - Chang, Chia-Yau
AU - Tsai , C-H
AU - Tsai, J-R
AU - Lai, Pei-Yi
AU - Liu, Y-L
AU - Hu, S.-H.
AU - Chen, Y.-C.
PY - 2019/6
Y1 - 2019/6
N2 - Aims : We presented our clinical experience that the product- switching, population pharmacokinetics, and the clinical experience of rFVIII- Fc for previously- treated patients (PTP) with hemophilia A. Methods : From Novmber, 2018 to February, 2019, there were to-tally 35 severe- type PTP with hemophilia A enrolled, five boys and 30 adults, who switched from rFVIII to rFVIII- Fc at Taipei Medical University Hospital. Pharmacokinetics(PK) study was performed from 3 to 5 spots of blood sampling and the individual half life was calculated through the WAPPS website. Other clinical data were also collected and analyzed.
AB - Aims : We presented our clinical experience that the product- switching, population pharmacokinetics, and the clinical experience of rFVIII- Fc for previously- treated patients (PTP) with hemophilia A. Methods : From Novmber, 2018 to February, 2019, there were to-tally 35 severe- type PTP with hemophilia A enrolled, five boys and 30 adults, who switched from rFVIII to rFVIII- Fc at Taipei Medical University Hospital. Pharmacokinetics(PK) study was performed from 3 to 5 spots of blood sampling and the individual half life was calculated through the WAPPS website. Other clinical data were also collected and analyzed.
UR - https://doi.org/10.1002/rth2.12229
M3 - Special issue
SN - 2475-0379
VL - 3
SP - 297
JO - Research and Practice in Thrombosis and Haemostasis
JF - Research and Practice in Thrombosis and Haemostasis
IS - S1
M1 - PB0289
ER -