TY - JOUR
T1 - The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells
AU - Yen, Gow Chin
AU - Chiang, Hsing Chang
AU - Wu, Chi Hao
AU - Yeh, Chi Tai
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/11/1
Y1 - 2003/11/1
N2 - The protective effects of 3,3″-di-OH-terphenyllin (3,3″-DHT) and 3-OH-terphenyllin (3-HT), two secondary metabolites produced by Aspergillus candidus (CCRC31543), against hydrogen peroxide-induced oxidative damage to Int 407 cells, were evaluated. The results showed that H 2O 2 caused an increase in lactate dehydrogenase (LDH) leakage and DNA damage in Int 407 cells; however, the addition of 3,3″-DHT and 3-HT significantly reduced this effect (P0.05), but oxidized glutathione levels increased when Int 407 cells were pre-incubated with these two compounds. These findings suggest that 3,3″-DHT and 3-HT have the ability to protect against oxidative damage to Int 407 cells and that this protective effect may be associated with the ability to reduce ROS formation and increase catalase activity.
AB - The protective effects of 3,3″-di-OH-terphenyllin (3,3″-DHT) and 3-OH-terphenyllin (3-HT), two secondary metabolites produced by Aspergillus candidus (CCRC31543), against hydrogen peroxide-induced oxidative damage to Int 407 cells, were evaluated. The results showed that H 2O 2 caused an increase in lactate dehydrogenase (LDH) leakage and DNA damage in Int 407 cells; however, the addition of 3,3″-DHT and 3-HT significantly reduced this effect (P0.05), but oxidized glutathione levels increased when Int 407 cells were pre-incubated with these two compounds. These findings suggest that 3,3″-DHT and 3-HT have the ability to protect against oxidative damage to Int 407 cells and that this protective effect may be associated with the ability to reduce ROS formation and increase catalase activity.
KW - 3,3″-Dihydroxyterphenyllin
KW - 3-Hydroxyterphenyllin
KW - Aspergillus candidus
KW - Int 407 cells
KW - Oxidative damage
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U2 - 10.1016/S0278-6915(03)00174-1
DO - 10.1016/S0278-6915(03)00174-1
M3 - Article
C2 - 12963009
AN - SCOPUS:0041378224
SN - 0278-6915
VL - 41
SP - 1561
EP - 1567
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - 11
ER -