The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

Cheng Kuei Chang; Fu Yu Chueh; Ming Tsuen Hsieh; Mao Tsun Lin

doi:10.1016/S0304-3940(99)00322-5

The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

Cheng Kuei Chang, Fu Yu Chueh, Ming Tsuen Hsieh, Mao Tsun Lin

研究成果: 雜誌貢獻 › 文章 › 同行評審

22 引文斯高帕斯（Scopus）

摘要

After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.

原文	英語
頁（從 - 到）	109-112
頁數	4
期刊	Neuroscience Letters
卷	267
發行號	2
DOIs	https://doi.org/10.1016/S0304-3940(99)00322-5
出版狀態	已發佈 - 5月 28 1999
對外發佈	是

ASJC Scopus subject areas

神經科學 (全部)

存取文件

10.1016/S0304-3940(99)00322-5

其它文件與鏈接

Link to publication in Scopus

引用此

@article{13c89decebd84e519c842d24c2087c9b,

title = "The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke",

abstract = "After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.",

keywords = "Brain, Cerebral ischemia, Heatstroke, Monoamines, Neuronal injury, Tetrahydroxypalmatine",

author = "Chang, {Cheng Kuei} and Chueh, {Fu Yu} and Hsieh, {Ming Tsuen} and Lin, {Mao Tsun}",

note = "Funding Information: This work was supported by the National Science Council (Taipei, Taiwan) Grant NSC87-2314-B-010-021 and the Ministry of Education grant NRICM–88108. ",

year = "1999",

month = may,

day = "28",

doi = "10.1016/S0304-3940(99)00322-5",

language = "English",

volume = "267",

pages = "109--112",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

AU - Chang, Cheng Kuei

AU - Chueh, Fu Yu

AU - Hsieh, Ming Tsuen

AU - Lin, Mao Tsun

N1 - Funding Information: This work was supported by the National Science Council (Taipei, Taiwan) Grant NSC87-2314-B-010-021 and the Ministry of Education grant NRICM–88108.

PY - 1999/5/28

Y1 - 1999/5/28

N2 - After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.

AB - After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.

KW - Brain

KW - Cerebral ischemia

KW - Heatstroke

KW - Monoamines

KW - Neuronal injury

KW - Tetrahydroxypalmatine

UR - http://www.scopus.com/inward/record.url?scp=0033612258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033612258&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(99)00322-5

DO - 10.1016/S0304-3940(99)00322-5

M3 - Article

C2 - 10400224

AN - SCOPUS:0033612258

SN - 0304-3940

VL - 267

SP - 109

EP - 112

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

引用此