@article{52ea8e4912ba4089a3772172041319a7,
title = "The mir-423-5p/mmp-2 axis regulates the nerve growth factor-induced promotion of chondrosarcoma metastasis",
abstract = "A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propen-sity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chon-drosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpres-sion of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma.",
keywords = "Chondrosarcoma, Metastasis, MiR-423-5p, MMP-2, NGF",
author = "Tzeng, {Huey En} and Lin, {Syuan Ling} and Thadevoos, {Louis Anoop} and Ko, {Chih Yuan} and Liu, {Ju Fang} and Huang, {Yu Wen} and Lin, {Chih Yang} and Fong, {Yi Chin} and Tang, {Chih Hsin}",
note = "Funding Information: Funding: This work was supported by grants from the Ministry of Science and Technology of Taiwan (MOST 107-2320-B-039-019-MY3, MOST 108-2314-B-039-034-MY3; MOST 109-2320-B-039-065), China Medical University Hospital (DMR-110-223, DMR-110-180), China Medical University Bei-gang Hospital (CMUBH R105-006) and Taipei Medical University (106TMU-TMUH-02). Funding Information: This work was supported by grants from the Ministry of Science and Technology of Taiwan (MOST 107-2320-B-039-019-MY3, MOST 108-2314-B-039-034-MY3; MOST 109-2320-B-039-065), China Medical University Hospital (DMR-110-223, DMR-110-180), China Medical University Beigang Hospital (CMUBH R105-006) and Taipei Medical University (106TMU-TMUH-02). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jul,
day = "1",
doi = "10.3390/cancers13133347",
language = "English",
volume = "13",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "13",
}
