@article{c0e05dac825d4d45ba5741caa36d99e0,
title = "The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock",
abstract = "The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus (SCN), remained uncompromised, while the kidney clock became a less robust circadian oscillator with a longer period. We find this analogous to the silencing of a strong slave clock in the brain, the choroid plexus, which alters the pacing of the SCN. We propose that the kidney also contributes to overall circadian timekeeping at the whole-body level, through bottom-up feedback in the hierarchical structure of the mammalian circadian clocks.",
keywords = "CKD, Circadian clocks, Hierarchical organization, Kidney, SCN, Systemic clocks",
author = "Jihwan Myung and Wu, {Mei Yi} and Lee, {Chun Ya} and Rahim, {Amalia Ridla} and Truong, {Vuong Hung} and Dean Wu and Piggins, {Hugh David} and Wu, {Mai Szu}",
note = "Funding Information: Acknowledgments: We thank Niall Duncan and Tzu-Yu Hsu at Taipei Medical University for help with the initial experimental setup (105-2410-H-038-006-MY3, 105-2410-H-038-005-MY2 to ND; 106-2410-H-038-004-MY2 to TYH), Rong-Chi Huang at Chang Gung University and Daisuke Ono at Nagoya University for advices and comments on experimental design, and Steven D. Aird at Okinawa Institute of Science and Technology and Niall Duncan for editorial support. We also thank the Taiwan Animal Consortium, Taiwan Mouse Clinic funded by MOST (107-2319-B-001-002) for technical support in animal blood testing. Funding Information: Funding: This work was supported by the Taiwan Ministry of Science and Technology (MOST) (grants 107-2311-B-038-001-MY2 and 107-2410-H-038-004-MY2 to J.M.), Taipei Medical University (TMU107-AE1-B15 and 107-3805-003-110 to J.M.; TMU105-AE1-B33 to M.Y.W.), Taipei Medical University-Shuang Ho Hospital (107TMU-SHH-03 to J.M. and D.W.), and the Nakayama Foundation for Human Science (to J.M.). H.D.P. is supported by the Biotechnology and Biological Sciences Research Council (BBSRC) (BB/M02329X and BB/R090223). Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = jun,
day = "1",
doi = "10.3390/ijms20112765",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "11",
}