The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

Li Ping Tseng; Hong Jen Liang; Ming Chung Deng; Kuo Ming Lee; Ryh Nan Pan; Jen Chang Yang; Yi You Huang; Der Zen Liu

doi:10.1016/j.tvjl.2009.05.019

The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

Li Ping Tseng
, Hong Jen Liang
, Ming Chung Deng
, Kuo Ming Lee
, Ryh Nan Pan
, Jen Chang Yang
, Yi You Huang
, Der Zen Liu

研究成果: 雜誌貢獻 › 文章 › 同行評審

20 引文斯高帕斯（Scopus）

摘要

The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P

原文	英語
頁（從 - 到）	204-210
頁數	7
期刊	Veterinary Journal
卷	185
發行號	2
DOIs	https://doi.org/10.1016/j.tvjl.2009.05.019
出版狀態	已發佈 - 8月 2010

ASJC Scopus subject areas

動物科學與動物學
一般獸醫學

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10.1016/j.tvjl.2009.05.019

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title = "The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease",

abstract = "The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P",

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AU - Tseng, Li Ping

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AU - Deng, Ming Chung

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AU - Pan, Ryh Nan

AU - Yang, Jen Chang

AU - Huang, Yi You

AU - Liu, Der Zen

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KW - Adjuvant

KW - Intranasal

KW - Liposome

KW - Newcastle disease virus

KW - S-IgA

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The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

摘要

ASJC Scopus subject areas

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