摘要
The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P
原文 | 英語 |
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頁(從 - 到) | 204-210 |
頁數 | 7 |
期刊 | Veterinary Journal |
卷 | 185 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 8月 2010 |
ASJC Scopus subject areas
- 動物科學與動物學
- 一般獸醫學