The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

Li Ping Tseng; Hong Jen Liang; Ming Chung Deng; Kuo Ming Lee; Ryh Nan Pan; Jen Chang Yang; Yi You Huang; Der Zen Liu

doi:10.1016/j.tvjl.2009.05.019

The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

Li Ping Tseng, Hong Jen Liang, Ming Chung Deng, Kuo Ming Lee, Ryh Nan Pan, Jen Chang Yang, Yi You Huang, Der Zen Liu

研究成果: 雜誌貢獻 › 文章 › 同行評審

20 引文斯高帕斯（Scopus）

摘要

The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P

原文	英語
頁（從 - 到）	204-210
頁數	7
期刊	Veterinary Journal
卷	185
發行號	2
DOIs	https://doi.org/10.1016/j.tvjl.2009.05.019
出版狀態	已發佈 - 8月 2010

ASJC Scopus subject areas

動物科學與動物學
獸醫 (全部)
醫藥 (全部)

UN SDG

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10.1016/j.tvjl.2009.05.019

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title = "The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease",

abstract = "The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P",

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author = "Tseng, {Li Ping} and Liang, {Hong Jen} and Deng, {Ming Chung} and Lee, {Kuo Ming} and Pan, {Ryh Nan} and Yang, {Jen Chang} and Huang, {Yi You} and Liu, {Der Zen}",

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AU - Deng, Ming Chung

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AU - Pan, Ryh Nan

AU - Yang, Jen Chang

AU - Huang, Yi You

AU - Liu, Der Zen

PY - 2010/8

Y1 - 2010/8

N2 - The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P

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KW - Intranasal

KW - Liposome

KW - Newcastle disease virus

KW - S-IgA

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The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

摘要

ASJC Scopus subject areas

UN SDG

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指紋

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