@article{d62765ef8ac6458aa5004c8908364b1e,
title = "The in Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma",
abstract = "Background/Aim: Radiation (RT) induced ERK/NF-?B in hepatocellular carcinoma (HCC) has been reported in our previous works; it weakens the toxicity of RT or triggers a radioresistance effect. Thus, combining RT with a suitable NF-?B inhibitor may sensitize HCC to RT. Magnolol, a bioactive compound, was known to have antiinflammatory and anti-tumor functions. Here, we aimed to investigate whether magnolol may enhance anti-HCC efficacy of RT in vivo. Materials and Methods: We established a Hep3B bearing mouse to evaluate the efficacy of the combination treatment of magnolol and RT. Results: Most significantly, tumor volume and tumor weight inhibition was found in the combination group. Tumor immunohistochemistry staining also illustrated the suppression of RT-induced ERK/NF-?B-related proteins expression by magnolol. In addition, intrinsic apoptosis-related proteins, such as caspase-3 and-9, were markedly increased in the combination group. Conclusion: Magnolol may effectively enhance anti-HCC ability of RT by downregulating the expression of ERK/NFB-related proteins and increasing the expression of apoptosis-related proteins.",
keywords = "Apoptosis, Hepatocellular carcinoma, Magnolol, Radiation",
author = "Chen, {Yu Shan} and Rou Sun and Chen, {Wei Lung} and Yau, {Yu Chen} and Hsu, {Fei Ting} and Chung, {Jing Gung} and Tsai, {Chia Jung} and Hsieh, {Chia Ling} and Chiu, {Ying Ming} and Chen, {Jiann Hwa}",
note = "Funding Information: This study was funded by Taipei Medical University, Taipei, Taiwan (Grant ID: 107TMU-TMUH-18). We also want to thanks to “TMU Research Center of Cancer Translational Medicine” from The Featured Areas Research Center Program within the framework of the Higher Education S prout Project by the Ministry of Education (MOE). This study was also supported by S how Chwan Memorial Hospital, Cathay General Hospital and China Medical University Hospital, respectively. (Grant ID: RD108023, CGH-MR-A10823 and DMR-109-172) Publisher Copyright: {\textcopyright} 2020 International Institute of Anticancer Research. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = aug,
doi = "10.21873/invivo.11973",
language = "English",
volume = "34",
pages = "1789--1796",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "4",
}