Background: Insulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain injury (mTBI) are not yet fully understood. This study attempted to elucidate the effects of IGF-1 variants on the risk and neuropsychiatric outcomes of mTBI. Methods: Based on 176 recruited mTBI patients and 1517 control subjects from the Taiwan Biobank project, we first compared the genotypic distributions of IGF-1 variants between the two groups. Then, we analyzed associations of IGF-1 variants with neuropsychiatric symptoms after mTBI, including anxiety, depression, dizziness, and sleep disturbances. Functional annotation of IGF-1 variants was also performed through bioinformatics databases. Results: The minor allele of rs7136446 was over-represented in mTBI patients compared to community-based control subjects. Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury. Conclusions: IGF-1 variants were associated with the risk and neuropsychiatric symptoms of mTBI. The findings highlight the important role of IGF-1 in the susceptibility and clinical outcomes of mTBI.
|期刊||Journal of Biomedical Science|
|出版狀態||已發佈 - 12月 2 2019|
ASJC Scopus subject areas
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MOESM1 of The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury
Wang, Y. (Contributor), Wong, H. (Contributor), Wu, C. (Contributor), Chiang, Y. (Contributor), Chiu, W. (Contributor), Chen, K. (Contributor) & Chang, W. (Contributor), Unknown Publisher, 1月 1 2019
DOI: 10.6084/m9.figshare.11302148.v1, https://springernature.figshare.com/articles/MOESM1_of_The_functional_roles_of_IGF-1_variants_in_the_susceptibility_and_clinical_outcomes_of_mild_traumatic_brain_injury/11302148/1