The effect of hyperbaric oxygen therapy on spinal fusion: Using the model of posterolateral intertransverse fusion in rabbits

Wen Jer Chen, Po Liang Lai, Chia Hsieh Chang, Mel S. Lee, Chih Hwa Chen, Ching Lung Tai

研究成果: 雜誌貢獻文章同行評審

23 引文 斯高帕斯(Scopus)

摘要

Background The purpose of this study is to evaluate the facilitating effect of hyperbaric oxygen (HBO) on posterolateral intertransverse fusion using a validated rabbit model.MethodsTwenty-four male New Zealand rabbits underwent posterolateral intertransverse fusion at L5-L6 with autogenous iliac bone graft. They were evenly divided into two groups: the HBO group and the normal room air (RA) group. Each group had six rabbits killed at 4 weeks and 8 weeks, respectively. The rabbits in the HBO groups were treated with 100% oxygen at 2.5 atm for 2 hours a day. After being killed, all rabbits were subjected to radiographic examination, manual testing, and torsional loading to evaluate the results of spinal fusion.ResultRadiographic union of intertransverse fusion areas at 4-week RA, 4-week HBO, 8-week RA, and 8-week HBO were 2 of 12, 7 of 12, 7 of 12, and 10 of 12, respectively. Solid union proven by manual palpation was found to be zero of six, three of six, four of six, and five of six of the cases, respectively. The average peak torsional momentums were 2120.2, 2576.5, 2661.6, and 3079.8 N-mm, respectively. Spinal fusion was significantly improved in the HBO groups at both 4 weeks and 8 weeks.ConclusionThe results of this study suggest that intermittent hyperbaric oxygen therapy will hasten the bone healing process and improve the fusion rate as compared with the non-HBO group.

原文英語
頁(從 - 到)333-338
頁數6
期刊Journal of Trauma
52
發行號2
DOIs
出版狀態已發佈 - 2月 2002
對外發佈

ASJC Scopus subject areas

  • 重症監護和重症監護醫學
  • 手術

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