The clinical outcomes and predictive factors for in-hospital mortality in non-neutropenic patients with candidemia

Recent epidemiologic studies have showed that candidemia is an important nosocomial infection in hospitalized patients. The majority of candidemia patients were non-neutropenic rather than neutropenic status. The aimof this studywas todetermine the clinical outcomeof non-neutropenic patients with candidemia and to measure the contributing factors formortality. A total of 163 non-neutropenic patients with candidemia during January 2010 to December 2013 were retrospectively enrolled. The patients' risk factors for mortality, clinical outcomes, treatment regimens, and Candida species were analyzed. The overall mortality was 54.6%. Candida albicans was themost frequent Candida species (n=83; 50.9% of patients). Under multivariate analyses, hemodialysis (OR, 4.554; 95% CI, 1.464-14.164) and the use of amphotericin B deoxycholate (OR, 8.709; 95%CI, 1.587-47.805) were independent factors associated withmortality. In contrast, abdominal surgery (OR, 0.360; 95%CI, 0.158-0.816)was associated with a better outcome. The overallmortality is still high in non-neutropenic patients with candidemia.Hemodialysis and use ofamphotericinBdeoxycholate were independent factors associated with mortality, whereas prior abdominal surgery was associated with a better outcome.