TY - JOUR
T1 - The clinical feature and treatment outcome of ocular melanoma
T2 - A 34-year experience in a tertiary referral center
AU - Huang, Yu Yun
AU - Hou, Tzu Yu
AU - Yu, Wei Kuang
AU - Tsai, Chieh Chih
AU - Kao, Shu Ching
AU - Hsu, Wen Ming
AU - Liu, Jui Ling
N1 - Funding Information:
This study was supported by the Ministry of Science and Technology, Executive Yuan, Taiwan (MOST 110-2314-B-075-064-MY2) and Taipei Veterans General Hospital, Taiwan (V110-C-008).
Funding Information:
Funding: This study was supported by the Ministry of Science and Technology, Executive Yuan,
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Malignant melanoma can arise from melanocytes in various structures of the eye, orbit, and ocular adnexa. We reviewed the clinical features and long-term results of all subjects with histologically proved melanoma originating from any of the ocular and periocular structures in a tertiary referral center. Overall, 88 patients including 47 men were recruited. The tumor was primarily located in the uvea, followed by the conjunctiva, orbit, eyelid, and lacrimal sac. Patients with uveal melanoma were diagnosed at a relatively younger age (47.0 years), while those with orbital and eyelid melanomas were older at presentation (79.5 years and 78.5 years, respectively). The overall local recurrence rate was 9% at a median follow-up of 41.0 months, among which orbital and eyelid melanomas recurred most commonly. The overall mortality rate was 41% in a median duration of 27.2 months (IQR, 13–58 months) from diagnosis, with the highest for lacrimal sac melanoma, followed by melanoma of the orbit, uveal, conjunctiva, and eyelid. Despite prompt local control, the risk for metastasis and mortality was high. Therefore, efficient modalities for early diagnosis and treatment of ocular melanoma are necessary.
AB - Malignant melanoma can arise from melanocytes in various structures of the eye, orbit, and ocular adnexa. We reviewed the clinical features and long-term results of all subjects with histologically proved melanoma originating from any of the ocular and periocular structures in a tertiary referral center. Overall, 88 patients including 47 men were recruited. The tumor was primarily located in the uvea, followed by the conjunctiva, orbit, eyelid, and lacrimal sac. Patients with uveal melanoma were diagnosed at a relatively younger age (47.0 years), while those with orbital and eyelid melanomas were older at presentation (79.5 years and 78.5 years, respectively). The overall local recurrence rate was 9% at a median follow-up of 41.0 months, among which orbital and eyelid melanomas recurred most commonly. The overall mortality rate was 41% in a median duration of 27.2 months (IQR, 13–58 months) from diagnosis, with the highest for lacrimal sac melanoma, followed by melanoma of the orbit, uveal, conjunctiva, and eyelid. Despite prompt local control, the risk for metastasis and mortality was high. Therefore, efficient modalities for early diagnosis and treatment of ocular melanoma are necessary.
KW - Conjunctival melanoma
KW - Eyelid melanoma
KW - Ocular melanoma
KW - Orbital melanoma
KW - Uveal melanoma
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U2 - 10.3390/cancers13235926
DO - 10.3390/cancers13235926
M3 - Article
AN - SCOPUS:85119682955
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 23
M1 - 5926
ER -
