The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population

Chun Yao Huang; Jong Shiuan Yeh; Chun Ming Shih; Feng Yen Lin; Yung Ta Kao; Nai Wen Tsao; Wen Tien Hsiao; Jaw Wen Chen; Nen Chung Chang; Kou-Gi Shyu

doi:10.2174/187152212802001848

The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population

Chun Yao Huang, Jong Shiuan Yeh, Chun Ming Shih, Feng Yen Lin, Yung Ta Kao, Nai Wen Tsao, Wen Tien Hsiao, Jaw Wen Chen, Nen Chung Chang, Kou-Gi Shyu

研究成果: 雜誌貢獻 › 文章 › 同行評審

摘要

Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and is independently associated with poor cardiovascular outcomes. However, the direct relationship between serum ADMA level and the extent of subclinical coronary atherosclerotic plaque has never been investigated. In total, 130 consecutive asymptomatic Taiwanese subjects (mean age, 55.6±10 years), who received a health screening evaluation, were enrolled. Coronary plaque detected by computed tomography coronary angiography (CTCA) was observed in 85 (65.4%) of 130 individuals. Patients with coronary plaque had a higher ADMA level (1.16±1.15 μmol/L vs. 0.42 ± 0.33 μmol /L, p

原文	英語
頁（從 - 到）	236-243
頁數	8
期刊	Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
卷	12
發行號	3
DOIs	https://doi.org/10.2174/187152212802001848
出版狀態	已發佈 - 2012

ASJC Scopus subject areas

內分泌學、糖尿病和代謝
免疫學和過敏
藥理

UN SDG

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10.2174/187152212802001848

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Huang, C. Y., Yeh, J. S., Shih, C. M., Lin, F. Y., Kao, Y. T., Tsao, N. W., Hsiao, W. T., Chen, J. W., Chang, N. C., & Shyu, K.-G. (2012). The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 12(3), 236-243. https://doi.org/10.2174/187152212802001848

Huang, CY , Yeh, JS , Shih, CM , Lin, FY , Kao, YT, Tsao, NW, Hsiao, WT, Chen, JW, Chang, NC & Shyu, K-G 2012, 'The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population', Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 卷 12, 編號 3, 頁 236-243. https://doi.org/10.2174/187152212802001848

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title = "The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population",

abstract = "Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and is independently associated with poor cardiovascular outcomes. However, the direct relationship between serum ADMA level and the extent of subclinical coronary atherosclerotic plaque has never been investigated. In total, 130 consecutive asymptomatic Taiwanese subjects (mean age, 55.6±10 years), who received a health screening evaluation, were enrolled. Coronary plaque detected by computed tomography coronary angiography (CTCA) was observed in 85 (65.4%) of 130 individuals. Patients with coronary plaque had a higher ADMA level (1.16±1.15 μmol/L vs. 0.42 ± 0.33 μmol /L, p",

keywords = "Asymmetric dimethylarginine (ADMA), Asymptomatic, Atherosclerotic plaque, Computed tomography coronary angiography (CTCA), Coronary atherosclerosis, Endothelial dysfunction, Nitric oxide (NO)",

author = "Huang, {Chun Yao} and Yeh, {Jong Shiuan} and Shih, {Chun Ming} and Lin, {Feng Yen} and Kao, {Yung Ta} and Tsao, {Nai Wen} and Hsiao, {Wen Tien} and Chen, {Jaw Wen} and Chang, {Nen Chung} and Kou-Gi Shyu",

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doi = "10.2174/187152212802001848",

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AU - Huang, Chun Yao

AU - Yeh, Jong Shiuan

AU - Shih, Chun Ming

AU - Lin, Feng Yen

AU - Kao, Yung Ta

AU - Tsao, Nai Wen

AU - Hsiao, Wen Tien

AU - Chen, Jaw Wen

AU - Chang, Nen Chung

AU - Shyu, Kou-Gi

PY - 2012

Y1 - 2012

N2 - Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and is independently associated with poor cardiovascular outcomes. However, the direct relationship between serum ADMA level and the extent of subclinical coronary atherosclerotic plaque has never been investigated. In total, 130 consecutive asymptomatic Taiwanese subjects (mean age, 55.6±10 years), who received a health screening evaluation, were enrolled. Coronary plaque detected by computed tomography coronary angiography (CTCA) was observed in 85 (65.4%) of 130 individuals. Patients with coronary plaque had a higher ADMA level (1.16±1.15 μmol/L vs. 0.42 ± 0.33 μmol /L, p

AB - Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and is independently associated with poor cardiovascular outcomes. However, the direct relationship between serum ADMA level and the extent of subclinical coronary atherosclerotic plaque has never been investigated. In total, 130 consecutive asymptomatic Taiwanese subjects (mean age, 55.6±10 years), who received a health screening evaluation, were enrolled. Coronary plaque detected by computed tomography coronary angiography (CTCA) was observed in 85 (65.4%) of 130 individuals. Patients with coronary plaque had a higher ADMA level (1.16±1.15 μmol/L vs. 0.42 ± 0.33 μmol /L, p

KW - Asymmetric dimethylarginine (ADMA)

KW - Asymptomatic

KW - Atherosclerotic plaque

KW - Computed tomography coronary angiography (CTCA)

KW - Coronary atherosclerosis

KW - Endothelial dysfunction

KW - Nitric oxide (NO)

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The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population

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UN SDG

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