The Ambivalent Role of lncRNA Xist in Carcinogenesis

Yung Kang Chen; Yun Yen

doi:10.1007/s12015-019-9871-z

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Yung Kang Chen, Yun Yen

研究成果: 雜誌貢獻 › 文章 › 同行評審

21 引文斯高帕斯（Scopus）

摘要

Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.

原文	英語
頁（從 - 到）	314-323
頁數	10
期刊	Stem Cell Reviews and Reports
卷	15
發行號	2
DOIs	https://doi.org/10.1007/s12015-019-9871-z
出版狀態	已發佈 - 4月 15 2019

ASJC Scopus subject areas

細胞生物學
癌症研究

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10.1007/s12015-019-9871-z

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abstract = "Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.",

keywords = "Cancer stem cell, Competing endogenous RNA, Exosomes, Long non-coding RNA, MicroRNAs, X Chromosome inactivation, XACT non-coding RNA, XIST non-coding RNA",

author = "Chen, {Yung Kang} and Yun Yen",

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KW - Competing endogenous RNA

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KW - MicroRNAs

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KW - XIST non-coding RNA

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The Ambivalent Role of lncRNA Xist in Carcinogenesis

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