The activation of EP300 by F11R leads to EMT and acts as a prognostic factor in triple-negative breast cancers

Chien-Hsiu Li, Chih-Yeu Fang, Ming-Hsien Chan, Pei-Jung Lu, Luo-Ping Ger, Jan-Show Chu, Yu-Chan Chang, Chi-Long Chen, Michael Hsiao

研究成果: 雜誌貢獻文章同行評審


Abstract Cancer progression is influenced by junctional adhesion molecule (JAM) family members. The relationship between JAM family members and different types of cancer was examined using The Cancer Genome Atlas dataset. mRNA levels of the F11R (F11 receptor) in tumours were inversely correlated to the expression of JAM-2 and JAM-3. This relationship was unique to breast cancer (BCa) and was associated with poor prognosis (p = 0.024, hazard ratio = 1.44 [1.05–1.99]). A 50-gene molecular signature (prediction analysis of microarray 50) was used to subtype BCa. F11R mRNA expression significantly increased in human epidermal growth factor receptor 2 (HER2)-enriched (p = 0.0035) and basal-like BCa tumours (p = 0.0005). We evaluated F11R protein levels in two different compositions of BCa subtype patient tissue array cohorts to determine the relationship between BCa subtype and prognosis. Immunohistochemistry staining revealed that a high F11R protein level was associated with poor overall survival (p 
期刊The Journal of Pathology: Clinical Research
出版狀態已發佈 - 2023