Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture

Junko Nakao; Wen Chang Chang; Sei Itsu Murota; Hajime Orimo

doi:10.1016/0021-9150(81)90070-8

Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture

Junko Nakao, Wen Chang Chang, Sei Itsu Murota, Hajime Orimo

研究成果: 雜誌貢獻 › 文章 › 同行評審

36 引文斯高帕斯（Scopus）

摘要

The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10^-10 - 10^-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10^-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.

原文	英語
頁（從 - 到）	203-209
頁數	7
期刊	Atherosclerosis
卷	39
發行號	2
DOIs	https://doi.org/10.1016/0021-9150(81)90070-8
出版狀態	已發佈 - 1981
對外發佈	是

ASJC Scopus subject areas

心臟病學與心血管醫學

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10.1016/0021-9150(81)90070-8

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title = "Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture",

abstract = "The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10-10 - 10-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.",

keywords = "Atherosclerosis, Prostacyclin, Rat aortic smooth muscle cells, Testosterone",

author = "Junko Nakao and Chang, {Wen Chang} and Murota, {Sei Itsu} and Hajime Orimo",

year = "1981",

doi = "10.1016/0021-9150(81)90070-8",

language = "English",

volume = "39",

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AU - Nakao, Junko

AU - Chang, Wen Chang

AU - Murota, Sei Itsu

AU - Orimo, Hajime

PY - 1981

Y1 - 1981

N2 - The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10-10 - 10-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.

AB - The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10-10 - 10-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.

KW - Atherosclerosis

KW - Prostacyclin

KW - Rat aortic smooth muscle cells

KW - Testosterone

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JO - Atherosclerosis

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ER -

Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture

摘要

ASJC Scopus subject areas

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