Terbutaline inhalation suppresses fentanyl-induced coughing

Ping Wing Lui, Chung Hsi Hsing, Ya Churn Chu

研究成果: 雜誌貢獻文章同行評審

23 引文 斯高帕斯(Scopus)


Purpose: To study the suppressive effect of inhalation of a selective β2-adrenergic bronchodilator terbutaline, and the effect of an intravenous anticholinergic, atropine, on fentanyl-induced coughing. Methods: We studied 131 ASA class I patients, aged 16-45 yr, scheduled for elective surgery, randomized into four groups. Fifteen minutes before bolus fentanyl (5 μg · kg-1, iv), patients inhaled either normal saline (4 ml; Group 1, n = 30) or terbutaline (5 mg in 2 ml normal saline; Group 2, n = 34) via a jet nebulizer. After inhalation of normal saline, patients in Group 3 (n = 32) received sterile water iv instead of fentanyl. Patients in Group 4 (n = 35) were pretreated with atropine (0.01 mg · kg-1, iv) 10 min before iv fentanyl bolus. The onset, frequency and intensity of cough were observed immediately by an anaesthetist blinded to the study. Results: The cough frequency was higher in Groups 1 (43%) and 4 (46%) than in Groups 2 (3%) and 3 (0%) (P < 0.05). The onset time and intensity of cough showed no difference among groups. No truncal rigidity was observed in patients receiving fentanyl bolus iv. The blood pressure, heart rate, and peripheral oxygen saturation did not change in Groups 1, 2, and 3, while patients in Group 4 showed an increase in heart rate (25.5 ± 15.2%). Conclusions: The inhalation of a selective β2-adrenergic bronchodilator, terbutaline, effectively inhibited fentanyl-induced cough, whereas atropine, an antimuscarinic vagolytic, had no efficacy. Our results suggest that bronchoconstriction may underlie the mechanism on fentanyl-induced cough.

頁(從 - 到)1216-1219
期刊Canadian Journal of Anaesthesia
出版狀態已發佈 - 12月 1996

ASJC Scopus subject areas

  • 麻醉與疼痛醫學


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