Temporal imprecision and phase instability in schizophrenia resting state EEG

Stephan Lechner, Georg Northoff

研究成果: 雜誌貢獻文章同行評審


Schizophrenia is characterized by temporal imprecision and irregularities on neuronal, psychological cognitive, and behavioral levels which are usually tested during task-related activity. This leaves open whether analogous temporal imprecision and irregularities can already be observed in the brain's spontaneous activity as measured during the resting state; this is the goal of our study. Building on recent task-related data, we, using EEG, aimed to investigate the temporal precision and regularity of phase coherence over time in healthy, schizophrenia, and bipolar disorder participants. To this end, we developed a novel methodology, nominal frequency phase stability (NFPS), that allows to measure stability over phase angles in selected frequencies. By applying sample entropy quantification to the time-series of the nominal frequency phase angle time series, we found increased irregularities in theta activity over a frontocentral electrode in schizophrenia but not in bipolar disorder. We therefore assume that temporal imprecision and irregularity already occur in the brain's spontaneous activity in schizophrenia.

期刊Asian Journal of Psychiatry
出版狀態已發佈 - 8月 2023

ASJC Scopus subject areas

  • 心理學(全部)
  • 精神病學和心理健康


深入研究「Temporal imprecision and phase instability in schizophrenia resting state EEG」主題。共同形成了獨特的指紋。